HitPredict

Interactor 1: SMAD6 (O43541)
Mothers against decapentaplegic homolog 6 (MAD homolog 6) (Mothers against DPP homolog 6) (SMAD family member 6) (SMAD 6) (Smad6) (hSMAD6)
Gene: SMAD6

Interactor 2: SMAD1 (Q15797)
Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (JV4-1) (Mad-related protein 1) (SMAD family member 1) (SMAD 1) (Smad1) (hSMAD1) (Transforming growth factor-beta-signaling protein 1) (BSP-1)
Gene: SMAD1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.80 1.00 0.900

The method score is based on:

Property Details
Experiments 9256479, 12857866, 9436979, 11483516
Identification Methods affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains MH1~MH1, MH2~MH2
Common GO terms GO:0000785 - chromatin
GO:0001657 - ureteric bud development
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
and 15 others

more...
Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 496
Hs

1 465
+ Hs
+ Hs
+ Hs
+ Mm
+ Hs
+ Mm
+ Dm
+ Hs
+ Hs
+ Hs
+ Hs
+ Mm
+ Hs
+ Mm
+ Hs
+ Dm
+ Dm
+ Hs
+ Mm

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024