HitPredict

Interactor 1: EFS (O43281)
Embryonal Fyn-associated substrate (hEFS) (Cas scaffolding protein family member 3)
Gene: EFS

Interactor 2: BCAR1 (P56945)
Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (Cas scaffolding protein family member 1) (p130cas)
Gene: BCAR1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	16169070
Identification Methods	two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	CAS_C~CAS_C
Common GO terms	GO:0005737 - cytoplasm GO:0005925 - focal adhesion GO:0007155 - cell adhesion GO:0007169 - cell surface receptor protein tyrosine kinase signaling pathway GO:0016477 - cell migration and 1 others more... GO:0017124 - SH3 domain binding
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 561 Hs			1 870
+	Hs
		942612 CASL_HUMAN (6-336): 1.95e-31: 131: 24.93		BCAR1_HUMAN (1-870): 1.95e-107: 353: 100.00
+	Hs
		942578 ACK1_HUMAN (9-484): 7.38e-24: 108: 14.85		BCAR1_HUMAN (1-870): 1.95e-107: 353: 100.00
+	Hs
		942908 CASS4_HUMAN (379-557): 1.44e-20: 97.8: 19.89		BCAR1_HUMAN (1-870): 1.95e-107: 353: 100.00
+	Hs
		215912 SYNJ1_HUMAN (95-472): 1.19e-18: 92.5: 13.96		BCAR1_HUMAN (1-870): 1.95e-107: 353: 100.00
+	Hs
		1127339 CASL_HUMAN (6-336): 1.95e-31: 131: 24.93		CASL_HUMAN (1-868): 5.72e-90: 305: 35.85
+	Hs
		942960 BCAR1_HUMAN (7-431): 3.42e-12: 71.3: 21.40		MACF1_HUMAN (505-867): 2.95e-74: 268: 13.79
+	Rn
		1216896 ACK1_RAT (9-484): 1.84e-28: 122: 15.84		ACK1_RAT (9-581): 6.84e-30: 129: 14.45
+	Mm
		236875 ACK1_MOUSE (11-484): 5.61e-29: 124: 15.31		ACK1_MOUSE (9-581): 2.89e-29: 127: 13.93
+	Mm
		236927 ACK1_MOUSE (11-484): 5.61e-29: 124: 15.31		MICA3_MOUSE (64-629): 2.43e-25: 115: 12.40
+	Hs
		1060768 ACK1_HUMAN (9-484): 7.38e-24: 108: 14.85		ACK1_HUMAN (9-499): 5.89e-30: 130: 15.35
+	Hs
		215925 SYNJ1_HUMAN (95-472): 1.19e-18: 92.5: 13.96		ITSN1_HUMAN (2-173): 5.21e-24: 111: 23.16
+	Hs
		1129637 MICA3_HUMAN (61-424): 2.26e-21: 100: 16.45		MDC1_HUMAN (56-759): 1.44e-20: 100: 8.77
+	Hs
		215938 SYNJ1_HUMAN (95-472): 1.19e-18: 92.5: 13.96		SH3K1_HUMAN (7-294): 1.08e-16: 86.7: 16.44
+	Hs
		942826 BCAR1_HUMAN (7-431): 3.42e-12: 71.3: 21.40		CHAP1_HUMAN (74-473): 9.53e-21: 100: 15.99
+	Hs
		942807 BCAR1_HUMAN (7-431): 3.42e-12: 71.3: 21.40		SH3K1_HUMAN (7-294): 1.08e-16: 86.7: 16.44