HitPredict

Interactor 1: HTRA2 (O43464)
Serine protease HTRA2, mitochondrial (EC 3.4.21.108) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine protease 25) (Serine proteinase OMI)
Gene: HTRA2

Interactor 2: MUL1 (Q969V5)
Mitochondrial ubiquitin ligase activator of NFKB 1 (EC 2.3.2.27) (E3 SUMO-protein ligase MUL1) (E3 ubiquitin-protein ligase MUL1) (Growth inhibition and death E3 ligase) (Mitochondrial-anchored protein ligase) (Protein Hades) (Putative NF-kappa-B-activating protein 266) (RING finger protein 218) (RING-type E3 ubiquitin transferase NFKB 1)
Gene: MUL1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	24709290
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005739 - mitochondrion GO:0016020 - membrane
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 458 Hs			1 352
+	Mm
		1222125 HTRA2_MOUSE (1-458): 0: 548: 84.93		XIAP_MOUSE (63-352): 5.08e-55: 189: 11.82
+	Hs
		216668 HTRA2_HUMAN (1-458): 0: 527: 100.00		XIAP_HUMAN (63-352): 1.22e-56: 193: 12.50
+	Hs
		216788 HTRA2_HUMAN (1-458): 0: 527: 100.00		BIRC8_HUMAN (65-352): 3.21e-54: 179: 12.25
+	Mm
		1223895 HTRA2_MOUSE (1-458): 0: 548: 84.93		BIRC2_MOUSE (63-352): 7.12e-42: 155: 13.65
+	Mm
		148450 HTRA2_MOUSE (1-458): 0: 548: 84.93		BIRC3_MOUSE (48-352): 3.15e-40: 151: 12.67
+	Hs
		216684 HTRA2_HUMAN (1-458): 0: 527: 100.00		BIRC2_HUMAN (63-352): 3.97e-39: 148: 12.81
+	Hs
		216683 HTRA2_HUMAN (1-458): 0: 527: 100.00		BIRC3_HUMAN (36-352): 2.94e-36: 140: 14.99
+	Hs
		1013363 HTRA3_HUMAN (28-456): 5.98e-163: 469: 42.86		XIAP_HUMAN (63-352): 1.22e-56: 193: 12.50
+	Mm
		59875 HTRA2_MOUSE (1-458): 0: 548: 84.93		BIRC7_MOUSE (260-352): 7.37e-19: 87.2: 26.88
+	Hs
		1022758 HTRA1_HUMAN (26-455): 5.47e-146: 427: 41.05		XIAP_HUMAN (63-352): 1.22e-56: 193: 12.50
+	Hs
		216765 HTRA2_HUMAN (1-458): 0: 527: 100.00		MYLIP_HUMAN (301-350): 3.04e-10: 63.3: 32.00
+	Hs
		1013285 HTRA4_HUMAN (28-455): 1.76e-125: 374: 38.67		XIAP_HUMAN (63-352): 1.22e-56: 193: 12.50
+	Dm
		1173361 HTRA2_DROME (141-455): 9.93e-118: 352: 50.15		DIAP2_DROME (63-352): 1.11e-61: 206: 15.29
+	Dm
		1173284 HTRA2_DROME (141-455): 9.93e-118: 352: 50.15		DIAP1_DROME (61-352): 1.21e-42: 155: 13.81