HitPredict

Interactor 1: MED14 (O60244)
Mediator of RNA polymerase II transcription subunit 14 (Activator-recruited cofactor 150 kDa component) (ARC150) (Cofactor required for Sp1 transcriptional activation subunit 2) (CRSP complex subunit 2) (Mediator complex subunit 14) (RGR1 homolog) (hRGR1) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170) (Transcriptional coactivator CRSP150) (Vitamin D3 receptor-interacting protein complex 150 kDa component) (DRIP150)
Gene: MED14

Interactor 2: TIF1B (Q13263)
Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28)
Gene: TRIM28

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	29955894
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003713 - transcription coactivator activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1454 Hs			1 835
+	Hs
		1029912 KI13B_HUMAN (961-1173): 3.7e-21: 103: 16.24		TIF1B_HUMAN (18-835): 3.77e-174: 525: 100.00
+	Hs
		1029750 CHAP1_HUMAN (919-1278): 9.7e-18: 91.5: 13.94		TIF1B_HUMAN (18-835): 3.77e-174: 525: 100.00
+	Hs
		1029691 CBP_HUMAN (900-1355): 2.7e-13: 77.7: 10.70		TIF1B_HUMAN (18-835): 3.77e-174: 525: 100.00
+	Hs
		624884 RPB1_HUMAN (1059-1159): 8.88e-09: 62.5: 23.30		TIF1B_HUMAN (18-835): 3.77e-174: 525: 100.00
+	Mm
		799603 CBP_MOUSE (836-1217): 4.2e-09: 63.8: 7.75		TIF1B_MOUSE (57-835): 5.81e-159: 486: 94.87
+	Hs
		668960 TB182_HUMAN (945-1135): 6.75e-20: 99.2: 18.33		PML_HUMAN (29-609): 1.21e-57: 214: 14.00
+	Hs
		1343634 KI13B_HUMAN (961-1173): 3.7e-21: 103: 16.24		TRI33_HUMAN (406-826): 1.6e-54: 206: 19.32
+	Hs
		170469 TB182_HUMAN (945-1135): 6.75e-20: 99.2: 18.33		TIF1A_HUMAN (404-808): 1.31e-52: 200: 21.55
+	Hs
		1295419 CHAP1_HUMAN (919-1278): 9.7e-18: 91.5: 13.94		TRI33_HUMAN (406-826): 1.6e-54: 206: 19.32
+	Hs
		1144617 TENS2_HUMAN (905-1243): 1.16e-17: 91.8: 14.14		TRIM8_HUMAN (59-589): 2.74e-56: 205: 16.09
+	Hs
		668872 CBP_HUMAN (900-1355): 2.7e-13: 77.7: 10.70		PML_HUMAN (29-609): 1.21e-57: 214: 14.00
+	Hs
		668617 IF4G1_HUMAN (840-1368): 3.72e-09: 63.8: 10.72		PML_HUMAN (29-609): 1.21e-57: 214: 14.00
+	Hs
		170437 CBP_HUMAN (900-1355): 2.7e-13: 77.7: 10.70		TIF1A_HUMAN (404-808): 1.31e-52: 200: 21.55
+	Hs
		980027 IF4G1_HUMAN (840-1368): 3.72e-09: 63.8: 10.72		TRI33_HUMAN (406-826): 1.6e-54: 206: 19.32
+	Hs
		170402 SRCAP_HUMAN (853-1422): 3.36e-09: 64.2: 9.60		TIF1A_HUMAN (404-808): 1.31e-52: 200: 21.55
+	Mm
		101463 F8VPR5_MOUSE (836-1217): 4.53e-09: 63.8: 7.75		TRI33_MOUSE (406-826): 4.38e-52: 199: 18.41