HitPredict

Interactor 1: SGTA (O43765)
Small glutamine-rich tetratricopeptide repeat-containing protein alpha (Alpha-SGT) (Vpu-binding protein) (UBP)
Gene: SGTA

Interactor 2: HUWE1 (Q7Z6Z7)
E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1)
Gene: HUWE1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	37167062
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 313 Hs			1 4374
+	Hs
		916681 PPP5_HUMAN (66-268): 8.29e-37: 139: 24.63		HUWE1_HUMAN (1-4374): 0: 3307: 100.00
+	Hs
		185816 OGT1_HUMAN (83-284): 7.91e-21: 94.9: 15.76		HUWE1_HUMAN (1-4374): 0: 3307: 100.00
+	Hs
		731425 STIP1_HUMAN (85-259): 1.56e-19: 90.7: 23.96		HUWE1_HUMAN (1-4374): 0: 3307: 100.00
+	Mm
		1274322 OGT1_MOUSE (83-284): 7.62e-21: 94.9: 15.76		HUWE1_MOUSE (1-4374): 0: 3269: 96.41
+	Hs
		923639 TTC3_HUMAN (75-310): 7.03e-40: 150: 20.90		SMUF2_HUMAN (3802-4371): 0: 615: 34.33
+	Hs
		861836 CHIP_HUMAN (66-229): 1.8e-41: 147: 27.22		NEDD4_HUMAN (3130-4372): 0: 612: 21.39
+	Ce
		1170400 Q21746_CAEEL (2-298): 3.25e-38: 139: 40.07		WWP1_CAEEL (3846-4372): 0: 616: 30.73
+	Hs
		131583 OGT1_HUMAN (83-284): 7.91e-21: 94.9: 15.76		WWP2_HUMAN (3506-4372): 0: 649: 23.78
+	Hs
		1394615 RPAP3_HUMAN (11-235): 5.51e-13: 71.4: 13.24		ITCH_HUMAN (3507-4372): 0: 670: 23.27
+	Hs
		731551 STIP1_HUMAN (85-259): 1.56e-19: 90.7: 23.96		NED4L_HUMAN (3517-4372): 0: 639: 26.97
+	Hs
		186040 OGT1_HUMAN (83-284): 7.91e-21: 94.9: 15.76		SMUF1_HUMAN (3746-4371): 0: 627: 31.96
+	Dm
		1475848 Q9VH81_DROME (65-239): 2.37e-41: 152: 28.81		Q9W325_DROME (3947-4373): 0: 569: 35.58
+	Hs
		132301 RPAP3_HUMAN (11-235): 5.51e-13: 71.4: 13.24		WWP2_HUMAN (3506-4372): 0: 649: 23.78
+	Sc
		1042266 SGT2_YEAST (2-298): 5.31e-38: 139: 28.45		TOM1_YEAST (3794-4374): 8.22e-157: 552: 40.72
+	Ce
		196767 OGT1_CAEEL (17-312): 1.61e-27: 114: 15.18		Q9GUP2_CAEEL (3486-4374): 7.75e-163: 573: 41.71
+	Hs
		861782 RPAP3_HUMAN (11-235): 5.51e-13: 71.4: 13.24		NEDD4_HUMAN (3130-4372): 0: 612: 21.39
+	Hs
		718643 CDC27_HUMAN (6-233): 1.22e-24: 106: 17.54		HECW2_HUMAN (3094-4373): 3.29e-171: 577: 19.18
+	Sc
		585649 STI1_YEAST (46-213): 7.63e-15: 76.7: 26.71		TOM1_YEAST (3794-4374): 8.22e-157: 552: 40.72