HitPredict

Interactor 1: O46034 (O46034)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27)
Gene: Cbl

Interactor 2: GRAP (Q08012)
Growth factor receptor-bound protein 2 (Downstream of receptor kinase) (Protein enhancer of sevenless 2B)
Gene: drk

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.643

Property	Details
Experiments	21340027, 10918586
Identification Methods	affinity chromatography technology, pull down, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001784 - phosphotyrosine residue binding GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0007476 - imaginal disc-derived wing morphogenesis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 448 Dm			1 211
+	Mm
		1189573 CBLB_MOUSE (33-431): 0: 730: 72.07		GRB2_MOUSE (1-210): 5.92e-63: 196: 63.08
+	Mm
		86322 B9EKI5_MOUSE (33-431): 0: 729: 72.07		GRB2_MOUSE (1-210): 5.92e-63: 196: 63.08
+	Ce
		711455 Q19019_CAEEL (2-435): 0: 732: 52.63		SEM5_CAEEL (1-211): 2.44e-61: 192: 61.03
+	Mm
		1189592 CBLB_MOUSE (33-431): 0: 730: 72.07		GRAP_MOUSE (1-210): 2.39e-55: 177: 52.78
+	Mm
		86321 B9EKI5_MOUSE (33-431): 0: 729: 72.07		LYN_MOUSE (3-199): 4.33e-35: 131: 24.29
+	Hs
		557275 CBLB_HUMAN (33-431): 0: 729: 72.07		SRC_HUMAN (4-208): 1.27e-32: 124: 25.65
+	Hs
		440057 CBLB_HUMAN (33-431): 0: 729: 72.07		LCK_HUMAN (3-200): 4.18e-32: 123: 26.54
+	Mm
		440278 CBLB_MOUSE (33-431): 0: 730: 72.07		LCK_MOUSE (3-200): 6.79e-32: 122: 26.07
+	Mm
		834251 CBLB_MOUSE (33-431): 0: 730: 72.07		CSK_MOUSE (2-136): 7.4e-26: 105: 36.99
+	Hs
		362274 CBLB_HUMAN (33-431): 0: 729: 72.07		ABL1_HUMAN (4-138): 2.71e-23: 99: 36.43
+	Hs
		72385 CBLB_HUMAN (33-431): 0: 729: 72.07		A9UF07_HUMAN (4-138): 7.53e-23: 97.8: 36.43
+	Mm
		86325 B9EKI5_MOUSE (33-431): 0: 729: 72.07		NCK1_MOUSE (5-143): 1.83e-20: 89.7: 32.35
+	Mm
		1189578 CBLB_MOUSE (33-431): 0: 730: 72.07		CRK_MOUSE (48-209): 2.19e-19: 85.9: 29.17
+	Hs
		584532 CBLB_HUMAN (33-431): 0: 729: 72.07		VAV_HUMAN (2-60): 9.91e-14: 71.2: 37.29
+	Ce
		234045 Q19019_CAEEL (2-435): 0: 732: 52.63		SRC2_CAEEL (114-211): 5.01e-11: 63.1: 18.00
+	Mm
		313432 CBLB_MOUSE (33-431): 0: 730: 72.07		GRAP2_MOUSE (3-58): 2.59e-11: 63.4: 33.93
+	Hs
		440531 CBLB_HUMAN (33-431): 0: 729: 72.07		FYN_HUMAN (157-211): 5.72e-11: 63.1: 28.07
+	Mm
		1189601 CBLB_MOUSE (33-431): 0: 730: 72.07		ITSN2_MOUSE (43-210): 3.25e-10: 61.2: 20.83
+	Hs
		292832 CBLB_HUMAN (33-431): 0: 729: 72.07		GRAP2_HUMAN (3-56): 8.49e-11: 62.2: 35.19
+	Hs
		463078 CBLB_HUMAN (33-431): 0: 729: 72.07		YES_HUMAN (63-211): 5.57e-10: 60: 14.57