HitPredict

Interactor 1: PLOD3 (O60568)
Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 [Includes: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 (EC 1.14.11.4) (Lysyl hydroxylase 3) (LH3); Procollagen glycosyltransferase (EC 2.4.1.50) (EC 2.4.1.66) (Galactosylhydroxylysine-glucosyltransferase) (Procollagen galactosyltransferase) (Procollagen glucosyltransferase)]
Gene: PLOD3

Interactor 2: COCA1 (Q99715)
Collagen alpha-1(XII) chain
Gene: COL12A1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005615 - extracellular space GO:0005788 - endoplasmic reticulum lumen GO:0030199 - collagen fibril organization GO:0062023 - collagen-containing extracellular matrix GO:0070062 - extracellular exosome
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 738 Hs			1 3063
+	Hs
		972806 PLOD1_HUMAN (32-738): 0: 1184: 59.38		COCA1_HUMAN (1-3015): 0: 1773: 98.55
+	Hs
		1223328 GT252_HUMAN (283-546): 5.69e-96: 312: 27.80		COCA1_HUMAN (1-3015): 0: 1773: 98.55
+	Hs
		237020 PLOD3_HUMAN (1-738): 0: 1310: 100.00		CO6A2_HUMAN (2737-2979): 6.76e-20: 100: 33.70
+	Hs
		237133 PLOD3_HUMAN (1-738): 0: 1310: 100.00		MARCO_HUMAN (2874-3062): 4.42e-18: 92.8: 37.32
+	Hs
		237111 PLOD3_HUMAN (1-738): 0: 1310: 100.00		COLA1_HUMAN (2625-2909): 1.93e-11: 72.4: 19.87
+	Hs
		237006 PLOD3_HUMAN (1-738): 0: 1310: 100.00		CO4A1_HUMAN (2739-2998): 7.89e-09: 63.9: 33.55
+	Hs
		129885 PLOD2_HUMAN (19-738): 0: 1217: 58.75		CO6A2_HUMAN (2737-2979): 6.76e-20: 100: 33.70
+	Hs
		129937 PLOD2_HUMAN (19-738): 0: 1217: 58.75		COLA1_HUMAN (2625-2909): 1.93e-11: 72.4: 19.87
+	Hs
		517998 PLOD1_HUMAN (32-738): 0: 1184: 59.38		CO6A2_HUMAN (2737-2979): 6.76e-20: 100: 33.70
+	Hs
		972726 PLOD1_HUMAN (32-738): 0: 1184: 59.38		COEA1_HUMAN (2852-3061): 1.05e-11: 73.5: 21.00
+	Hs
		972805 PLOD1_HUMAN (32-738): 0: 1184: 59.38		COLA1_HUMAN (2625-2909): 1.93e-11: 72.4: 19.87
+	Hs
		358604 PLOD1_HUMAN (32-738): 0: 1184: 59.38		CO2A1_HUMAN (2782-3053): 1.78e-10: 69.3: 33.14
+	Hs
		358661 PLOD1_HUMAN (32-738): 0: 1184: 59.38		CO4A1_HUMAN (2739-2998): 7.89e-09: 63.9: 33.55
+	Dm
		435988 PLOD_DROME (37-738): 0: 1033: 46.03		CO4A1_DROME (2747-2869): 1.76e-13: 79.3: 39.01
+	Hs
		518024 GT251_HUMAN (279-546): 1.17e-98: 319: 21.74		CO6A2_HUMAN (2737-2979): 6.76e-20: 100: 33.70
+	Hs
		518019 GT252_HUMAN (283-546): 5.69e-96: 312: 27.80		CO6A2_HUMAN (2737-2979): 6.76e-20: 100: 33.70
+	Hs
		1223326 GT252_HUMAN (283-546): 5.69e-96: 312: 27.80		COLA1_HUMAN (2625-2909): 1.93e-11: 72.4: 19.87
+	Hs
		358613 GT252_HUMAN (283-546): 5.69e-96: 312: 27.80		CO2A1_HUMAN (2782-3053): 1.78e-10: 69.3: 33.14
+	Hs
		358664 GT252_HUMAN (283-546): 5.69e-96: 312: 27.80		CO4A1_HUMAN (2739-2998): 7.89e-09: 63.9: 33.55