Interactor 1: TLR2 (O60603)
Toll-like receptor 2 (Toll/interleukin-1 receptor-like protein 4) (CD antigen CD282)
Gene: TLR2

Interactor 2: TLR2 (O60603)
Toll-like receptor 2 (Toll/interleukin-1 receptor-like protein 4) (CD antigen CD282)
Gene: TLR2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.61 1.00 0.786

The method score is based on:

Property Details
Experiments 10395652, 23155421
Identification Methods affinity chromatography technology, tox-r dimerization assay, fluorescence technology, cosedimentation in solution
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains LRR_1~LRR_1, LRR_1~LRR_8, LRR_8~LRR_8, LRR_8~LRRCT, TIR~TIR
Common GO terms GO:0001530 - lipopolysaccharide binding
GO:0001540 - amyloid-beta binding
GO:0001666 - response to hypoxia
GO:0001774 - microglial cell activation
GO:0001875 - lipopolysaccharide immune receptor activity
and 68 others

more...

Homologous interactions 14

Homologous interactions

Color coding for hit scores

1 784
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024