Interactor 1: TLR2 (O60603)
Toll-like receptor 2 (Toll/interleukin-1 receptor-like protein 4) (CD antigen CD282)
Gene: TLR2

Interactor 2: TLR10 (Q9BXR5)
Toll-like receptor 10 (CD antigen CD290)
Gene: TLR10

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.67 1.00 0.821

The method score is based on:

Property Details
Experiments 15728506, 20348427, 23155421
Identification Methods anti tag coimmunoprecipitation, tox-r dimerization assay
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains LRR_1~LRR_8, LRR_8~LRR_8, LRR_8~LRRCT, TIR~TIR
Common GO terms GO:0002224 - toll-like receptor signaling pathway
GO:0004888 - transmembrane signaling receptor activity
GO:0005886 - plasma membrane
GO:0006954 - inflammatory response
GO:0006955 - immune response
and 5 others

more...

Homologous interactions 15

Homologous interactions

Color coding for hit scores

1 784
Hs

1 811
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024