HitPredict

Interactor 1: TLR2 (O60603)
Toll-like receptor 2 (Toll/interleukin-1 receptor-like protein 4) (CD antigen CD282)
Gene: TLR2

Interactor 2: TLR6 (Q9Y2C9)
Toll-like receptor 6 (CD antigen CD286)
Gene: TLR6

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.59 1.00 0.769

The method score is based on:

Property Details
Experiments 23155421, 20067962
Identification Methods tox-r dimerization assay, fluorescent resonance energy transfer, cosedimentation in solution, anti bait coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains LRR_1~LRR_8, LRR_8~LRR_8, LRR_8~LRRCT, TIR~TIR
Common GO terms GO:0001540 - amyloid-beta binding
GO:0001774 - microglial cell activation
GO:0002224 - toll-like receptor signaling pathway
GO:0004888 - transmembrane signaling receptor activity
GO:0005794 - Golgi apparatus
and 17 others

more...
Homologous interactions 15

Homologous interactions

Color coding for hit scores

1 784
Hs

1 796
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Last updated: 15 Jul 2024