Interactor 1: GEMI (O75496)
Geminin
Gene: GMNN

Interactor 2: CDT1 (Q9H211)
DNA replication factor Cdt1 (Double parked homolog) (DUP)
Gene: CDT1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.992

The method score is based on:

Property Details
Experiments 14578910, 26496610, 28514442, 33961781, 34599168, 15257290, 15138268, 17261582, 27107012, 30018425, 31160578, 18617514, 18162579, 18184650, 20980834, 14993212, 15855168, 15232106, 22581055, 19906994 and 4 others

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Identification Methods affinity chromatography technology, two hybrid, pull down, surface plasmon resonance, molecular sieving, x-ray crystallography, x ray scattering, anti tag coimmunoprecipitation, validated two hybrid, protein array and 3 others

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Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains CDT1~Geminin
Common GO terms GO:0003682 - chromatin binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0030174 - regulation of DNA-templated DNA replication initiation
GO:0035563 - positive regulation of chromatin binding
and 3 others

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Homologous interactions 3

Homologous interactions

Color coding for hit scores

1 209
Hs

1 546
+ Mm
+ Hs
+ Xl

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024