HitPredict

Interactor 1: SRGP2 (O75044)
SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2) (Rho GTPase-activating protein 34)
Gene: SRGAP2

Interactor 2: RHOQ (P17081)
Rho-related GTP-binding protein RhoQ (Ras-like protein TC10) (Ras-like protein family member 7A)
Gene: RHOQ

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~RhoGAP
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1071 Hs			1 205
+	Hs
		269537 SRGP2_HUMAN (1-1071): 0: 702: 100.00		RAC1_HUMAN (10-195): 2.03e-80: 239: 63.98
+	Hs
		269533 SRGP2_HUMAN (1-1071): 0: 702: 100.00		RAC3_HUMAN (10-183): 3.69e-76: 228: 66.67
+	Mm
		1362439 SRGP1_MOUSE (1-1071): 0: 616: 66.48		RHOA_MOUSE (1-204): 1.03e-76: 230: 49.02
+	Hs
		988485 SRGP1_HUMAN (1-1071): 0: 605: 65.01		RAC1_HUMAN (10-195): 2.03e-80: 239: 63.98
+	Mm
		953811 SRGP1_MOUSE (1-1071): 0: 616: 66.48		CDC42_MOUSE (9-193): 3.18e-75: 226: 67.57
+	Hs
		962215 SRGP1_HUMAN (1-1071): 0: 605: 65.01		RHOA_HUMAN (1-201): 1.72e-76: 229: 49.75
+	Hs
		212765 SRGP3_HUMAN (1-1056): 0: 588: 56.80		RAC1_HUMAN (10-195): 2.03e-80: 239: 63.98
+	Hs
		988277 RHG04_HUMAN (1-924): 1.07e-133: 430: 40.25		RAC1_HUMAN (10-195): 2.03e-80: 239: 63.98
+	Dm
		828028 CDGAP_DROME (451-1069): 4.9e-96: 338: 17.78		RAC1_DROME (10-195): 5.51e-77: 230: 63.98
+	Hs
		962118 RHG29_HUMAN (29-1011): 1.46e-96: 335: 16.23		RHOA_HUMAN (1-201): 1.72e-76: 229: 49.75
+	Hs
		978051 RHG29_HUMAN (29-1011): 1.46e-96: 335: 16.23		RHOB_HUMAN (1-204): 2.53e-75: 226: 49.51
+	Hs
		65907 RHG42_HUMAN (127-958): 7.77e-88: 304: 15.30		RAC1_HUMAN (10-195): 2.03e-80: 239: 63.98
+	Hs
		260707 OPHN1_HUMAN (127-922): 7.68e-88: 302: 14.82		RAC1_HUMAN (10-195): 2.03e-80: 239: 63.98
+	Hs
		65899 RHG42_HUMAN (127-958): 7.77e-88: 304: 15.30		RAC2_HUMAN (10-196): 9.52e-77: 230: 62.03
+	Hs
		65906 RHG42_HUMAN (127-958): 7.77e-88: 304: 15.30		RAC3_HUMAN (10-183): 3.69e-76: 228: 66.67
+	Hs
		260706 OPHN1_HUMAN (127-922): 7.68e-88: 302: 14.82		RHOA_HUMAN (1-201): 1.72e-76: 229: 49.75
+	Hs
		260705 OPHN1_HUMAN (127-922): 7.68e-88: 302: 14.82		CDC42_HUMAN (9-193): 3.18e-75: 226: 67.57
+	Dm
		828044 RHGF_DROME (127-1067): 2.23e-84: 297: 13.13		RAC1_DROME (10-195): 5.51e-77: 230: 63.98
+	Hs
		962580 GMIP_HUMAN (31-893): 1.87e-83: 294: 13.95		RHOA_HUMAN (1-201): 1.72e-76: 229: 49.75
+	Hs
		955698 GMIP_HUMAN (31-893): 1.87e-83: 294: 13.95		CDC42_HUMAN (9-193): 3.18e-75: 226: 67.57