HitPredict

Interactor 1: SKAP2 (O75563)
Src kinase-associated phosphoprotein 2 (Pyk2/RAFTK-associated protein) (Retinoic acid-induced protein 70) (SKAP55 homolog) (SKAP-55HOM) (SKAP-HOM) (Src family-associated phosphoprotein 2) (Src kinase-associated phosphoprotein 55-related protein) (Src-associated adapter protein with PH and SH3 domains)
Gene: SKAP2

Interactor 2: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.752

Property	Details
Experiments	27956147
Identification Methods	two hybrid, affinity chromatography technology, ubiquitin reconstruction, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 359 Hs			1 1210
+	Hs
		338764 CNKR2_HUMAN (87-295): 1.45e-45: 168: 20.00		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		338561 PKHA7_HUMAN (26-316): 3.97e-42: 159: 14.52		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		338998 PKHA5_HUMAN (27-326): 3.7e-39: 150: 15.86		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		338081 TEC_HUMAN (123-354): 7.46e-31: 125: 18.07		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		338167 VAV2_HUMAN (151-355): 2.94e-28: 118: 15.53		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		788994 TEC_HUMAN (123-354): 7.46e-31: 125: 18.07		ERBB4_HUMAN (1-1199): 0: 1137: 49.46
+	Hs
		855797 VAV2_HUMAN (151-355): 2.94e-28: 118: 15.53		ERBB4_HUMAN (1-1199): 0: 1137: 49.46
+	Hs
		383671 TEC_HUMAN (123-354): 7.46e-31: 125: 18.07		ERBB2_HUMAN (5-1200): 0: 1111: 48.49
+	Hs
		383705 VAV2_HUMAN (151-355): 2.94e-28: 118: 15.53		ERBB2_HUMAN (5-1200): 0: 1111: 48.49
+	Hs
		601835 TEC_HUMAN (123-354): 7.46e-31: 125: 18.07		ERBB3_HUMAN (1-1210): 0: 1080: 40.95
+	Hs
		601860 VAV2_HUMAN (151-355): 2.94e-28: 118: 15.53		ERBB3_HUMAN (1-1210): 0: 1080: 40.95
+	Hs
		665661 PKHA5_HUMAN (27-326): 3.7e-39: 150: 15.86		EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76
+	Hs
		1072602 PKHA5_HUMAN (27-326): 3.7e-39: 150: 15.86		EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23
+	Hs
		855777 VAV2_HUMAN (151-355): 2.94e-28: 118: 15.53		EPHA4_HUMAN (660-1016): 3.35e-120: 398: 31.52
+	Hs
		411481 CYH2_HUMAN (65-243): 5.57e-33: 128: 16.50		INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87
+	Hs
		212302 CYH3_HUMAN (65-215): 8.9e-33: 127: 19.77		INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87
+	Hs
		983669 PKHA4_HUMAN (83-293): 2.34e-28: 118: 15.28		FAK1_HUMAN (716-991): 1.58e-53: 206: 37.68
+	Hs
		796531 VAV2_HUMAN (151-355): 2.94e-28: 118: 15.53		KSYK_HUMAN (716-961): 1.13e-53: 201: 41.70
+	Hs
		796651 PKHA4_HUMAN (83-293): 2.34e-28: 118: 15.28		KSYK_HUMAN (716-961): 1.13e-53: 201: 41.70
+	Hs
		435765 PKHA5_HUMAN (27-326): 3.7e-39: 150: 15.86		IGF1R_HUMAN (354-658): 1.12e-14: 81.4: 18.47