HitPredict

Interactor 1: MEGF6 (O75095)
Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3)
Gene: MEGF6

Interactor 2: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.61	0.50	0.555

Property	Details
Experiments	20029029, unassigned2173
Identification Methods	protein complementation assay, ubiquitin reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1541 Hs			1 1210
+	Hs
		362948 NOTC1_HUMAN (27-711): 3.36e-49: 195: 16.34		EGFR_HUMAN (1-1210): 0: 1246: 100.00
+	Hs
		362790 TENA_HUMAN (27-414): 2.37e-31: 137: 14.90		EGFR_HUMAN (1-1210): 0: 1246: 100.00
+	Mm
		312048 SORL_MOUSE (1159-1519): 5.74e-20: 99.7: 15.12		EGFR_MOUSE (1-1210): 0: 1267: 90.35
+	Hs
		362877 FBN2_HUMAN (965-1539): 5.76e-17: 89.7: 16.61		EGFR_HUMAN (1-1210): 0: 1246: 100.00
+	Hs
		363162 NOTC2_HUMAN (1340-1541): 1.78e-12: 75: 20.59		EGFR_HUMAN (1-1210): 0: 1246: 100.00
+	Hs
		410705 NOTC1_HUMAN (27-711): 3.36e-49: 195: 16.34		ERBB2_HUMAN (5-1203): 0: 1119: 48.38
+	Hs
		410766 JAG1_HUMAN (1060-1541): 4.94e-28: 125: 18.86		ERBB2_HUMAN (5-1203): 0: 1119: 48.38
+	Mm
		312047 SORL_MOUSE (1159-1519): 5.74e-20: 99.7: 15.12		ERBB2_MOUSE (5-1203): 0: 1131: 48.34
+	Hs
		410975 SORL_HUMAN (1153-1519): 1.4e-19: 98.2: 15.22		ERBB2_HUMAN (5-1203): 0: 1119: 48.38
+	Hs
		641643 SORL_HUMAN (1153-1519): 1.4e-19: 98.2: 15.22		ERBB3_HUMAN (1-1205): 0: 1102: 41.39
+	Hs
		464078 NOTC3_HUMAN (518-1541): 1.75e-79: 293: 20.12		RET_HUMAN (412-1058): 7.91e-132: 433: 23.02
+	Dm
		451752 NOTCH_DROME (40-670): 1.92e-44: 180: 13.69		Q0KIF4_DROME (621-1017): 1.11e-113: 382: 32.07
+	Mm
		312049 SORL_MOUSE (1159-1519): 5.74e-20: 99.7: 15.12		EPHA4_MOUSE (660-1069): 1.99e-122: 404: 28.27
+	Hs
		710535 TEN3_HUMAN (47-317): 8.56e-26: 118: 14.84		EPHA2_HUMAN (665-1016): 2.96e-113: 379: 32.79
+	Dm
		1172550 DRPR_DROME (20-596): 9.81e-28: 124: 13.43		SHARK_DROME (691-975): 7.24e-53: 203: 39.52
+	Hs
		849226 MEG10_HUMAN (50-494): 2.64e-26: 119: 12.29		KSYK_HUMAN (716-961): 1.14e-53: 201: 41.70
+	Hs
		849187 PEAR1_HUMAN (6-372): 1.22e-22: 107: 16.80		KSYK_HUMAN (716-961): 1.14e-53: 201: 41.70
+	Hs
		849073 PEAR1_HUMAN (6-372): 1.22e-22: 107: 16.80		ZAP70_HUMAN (718-961): 5.6e-53: 199: 39.59
+	Mm
		312044 SORL_MOUSE (1159-1519): 5.74e-20: 99.7: 15.12		INSR_MOUSE (336-637): 2.12e-27: 122: 21.64
+	Hs
		439665 FBN2_HUMAN (965-1539): 5.76e-17: 89.7: 16.61		INSR_HUMAN (336-637): 2.63e-27: 122: 21.64