Interactor 1: CDC45 (O75419)
Cell division control protein 45 homolog (PORC-PI-1)
Gene: CDC45
Interactor 2: MCM2 (P49736)
DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28)
Gene: MCM2
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.88 | 1.00 | 0.939 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 22374673, 23364835, 30392930, 31067464, 19805216, 26167883 |
| Identification Methods | fluorescent resonance energy transfer, affinity chromatography technology, bimolecular fluorescence complementation, anti tag coimmunoprecipitation |
| Interaction Type | direct interaction, physical association, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | CDC45~MCM_lid, CDC45~MCM_N, CDC45~MCM_OB |
| Common GO terms | GO:0000727 - double-strand break repair via break-induced replication GO:0003688 - DNA replication origin binding GO:0003697 - single-stranded DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm and 2 others more... |
| Homologous interactions | 14 |
Homologous interactions
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
