Protein: CDC45
Cell division control protein 45

Gene: CDC45
Organism: Saccharomyces cerevisiae S288C
Interactions: 62
UniProt ID: Q08032

Gene Ontology (top 5):
GO:0000727 - double-strand break repair via break-induced replication
GO:0003682 - chromatin binding
GO:0003688 - DNA replication origin binding
GO:0003697 - single-stranded DNA binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

721420

MCM4
DNA replication licensing factor MCM4

27

16

Small-scale

0.990

High

1042682

SLD5
DNA replication complex GINS protein SLD5

24

3

Small-scale

0.990

High

713045

MCM2
DNA replication licensing factor MCM2

22

15

Small-scale

0.990

High

664472

MCM3
DNA replication licensing factor MCM3

19

15

Small-scale

0.985

High

713311

MCM5
Minichromosome maintenance protein 5

17

17

Small-scale

0.983

High

917071

MCM6
DNA replication licensing factor MCM6

15

18

Small-scale

0.981

High

794101

MCM7
DNA replication licensing factor MCM7

14

15

Small-scale

0.980

High

823320

PSF2
DNA replication complex GINS protein PSF2

8

3

Small-scale

0.959

High

1030405

CTF4
DNA polymerase alpha-binding protein

8

1

Small-scale

0.957

High

1061506

PSF1
DNA replication complex GINS protein PSF1

6

3

Small-scale

0.936

High

917532

SLD3
DNA replication regulator SLD3

12

0

Small-scale

0.932

High

1061504

PSF3
DNA replication complex GINS protein PSF3

4

2

Small-scale

0.885

High

1061500

CDC45
Cell division control protein 45

2

0

Small-scale

0.758

High

735412

MCM10
Minichromosome maintenance protein 10

9

2

Small-scale

0.753

High

665209

DPB2
DNA polymerase epsilon subunit B

6

1

Small-scale

0.719

High

561335

DPOLA
DNA polymerase alpha catalytic subunit A

5

4

Small-scale

0.714

High

923799

TOF1
Topoisomerase 1-associated factor 1

4

1

Small-scale

0.683

High

677707

MRC1
Mediator of replication checkpoint protein 1

5

0

Small-scale

0.676

High

646550

RAD53
Serine/threonine-protein kinase RAD53

2

1

Small-scale

0.642

High

642079

DPOE
DNA polymerase epsilon catalytic subunit A

3

4

Small-scale

0.641

High

1047268

CSM3
Chromosome segregation in meiosis protein 3

3

0

Small-scale

0.619

High

864253

DPB11
DNA replication regulator DPB11

2

1

Small-scale

0.602

High

647847

RFA1
Replication factor A protein 1

2

1

Small-scale

0.584

High

650025

SIN3
Transcriptional regulatory protein SIN3

2

0

High-throughput

0.576

High

739919

RPD3
Histone deacetylase RPD3

2

0

High-throughput

0.576

High

1061502

DIA2
Protein DIA2

2

0

Small-scale

0.547

High

1039055

IMA1
Importin subunit alpha

1

2

Small-scale

0.501

High

402136

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

1

Small-scale

0.479

High

737959

HOG1
Mitogen-activated protein kinase HOG1

1

2

Small-scale

0.479

High

916750

UFD1
Ubiquitin fusion degradation protein 1

1

1

Small-scale

0.479

High

808241

SHU2
Suppressor of hydroxyurea sensitivity protein 2

1

0

Small-scale

0.460

High

824978

CSM2
Chromosome segregation in meiosis protein 2

1

0

Small-scale

0.460

High

1061505

PSY3
Platinum sensitivity protein 3

1

0

Small-scale

0.460

High

548805

MCM1
Pheromone receptor transcription factor

1

0

Small-scale

0.458

High

626904

HSP60
Heat shock protein 60, mitochondrial

1

0

High-throughput

0.458

High

708362

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

801141

NSE2
E3 SUMO-protein ligase MMS21

1

0

Small-scale

0.458

High

892818

CTF18
Chromosome transmission fidelity protein 18

1

0

Small-scale

0.458

High

1025193

SEN1
Helicase SEN1

1

0

Small-scale

0.458

High

1044792

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

1053988

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.458

High

1061501

SLD7
Mitochondrial morphogenesis protein SLD7

1

0

Small-scale

0.458

High

546517

SSB1
Ribosome-associated molecular chaperone SSB1

1

1

High-throughput

0.445

High

676410

MAS5
Mitochondrial protein import protein MAS5

1

1

High-throughput

0.445

High

819963

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.445

High

1061503

CDC53
Cell division control protein 53

1

1

High-throughput

0.445

High

382384

H4
Histone H4

1

0

High-throughput

0.426

High

403677

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

0

High-throughput

0.426

High

527841

HSP72
Heat shock protein SSA2

1

0

High-throughput

0.426

High

690747

DPB3
DNA polymerase epsilon subunit C

1

0

Small-scale

0.426

High

910795

SKP1
Suppressor of kinetochore protein 1

1

0

High-throughput

0.426

High

1046896

DPB4
DNA polymerase epsilon subunit D

1

0

Small-scale

0.426

High

1061507

H2AZ
Histone H2A.Z

1

0

High-throughput

0.426

High

825486

LYS12
Homoisocitrate dehydrogenase, mitochondrial

2

0

High-throughput

0.313

High

1035374

TOF2
Topoisomerase 1-associated factor 2

1

0

Small-scale

0.249

Low

386884

TBB
Tubulin beta chain

1

0

High-throughput

0.232

Low

394954

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.232

Low

453826

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.232

Low

592539

VATB
V-type proton ATPase subunit B

1

0

High-throughput

0.232

Low

739796

SPT16
FACT complex subunit SPT16

1

0

High-throughput

0.232

Low

836926

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025