Protein: CDC45
Cell division control protein 45 homolog (PORC-PI-1)

Gene: CDC45
Organism: Homo sapiens
Interactions: 132
UniProt ID: O75419

Gene Ontology (top 5):
GO:0000076 - DNA replication checkpoint signaling
GO:0000727 - double-strand break repair via break-induced replication
GO:0003682 - chromatin binding
GO:0003688 - DNA replication origin binding
GO:0003697 - single-stranded DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

281194

MCM2
DNA replication licensing factor MCM2

6

14

Small-scale

0.939

High

281243

SLD5
DNA replication complex GINS protein SLD5

5

3

Small-scale

0.920

High

281183

MCM7
DNA replication licensing factor MCM7

4

17

Small-scale

0.878

High

281208

MCM6
DNA replication licensing factor MCM6

3

18

Small-scale

0.835

High

281176

MCM3
DNA replication licensing factor MCM3

3

18

Small-scale

0.829

High

281209

PSF1
DNA replication complex GINS protein PSF1

2

3

Small-scale

0.798

High

281244

PSF3
DNA replication complex GINS protein PSF3

2

2

Small-scale

0.789

High

281266

PSF2
DNA replication complex GINS protein PSF2

2

3

Small-scale

0.789

High

281181

MCM4
DNA replication licensing factor MCM4

2

14

Small-scale

0.754

High

281236

TOPB1
DNA topoisomerase 2-binding protein 1

3

1

Small-scale

0.670

High

281215

CEP55
Centrosomal protein of 55 kDa

4

0

High-throughput

0.668

High

281173

RFA2
Replication protein A 32 kDa subunit

4

0

Small-scale

0.657

High

281250

CLSPN
Claspin

3

0

Small-scale

0.652

High

281155

WDHD1
WD repeat and HMG-box DNA-binding protein 1

1

1

Small-scale

0.618

High

281182

MCM5
DNA replication licensing factor MCM5

1

16

Small-scale

0.618

High

281207

CUL3
Cullin-3

2

1

High-throughput

0.611

High

281263

ZRAN1
Ubiquitin thioesterase ZRANB1

2

0

High-throughput

0.580

High

281158

RECQ4
ATP-dependent DNA helicase Q4

2

0

Small-scale

0.559

High

281190

CCNF
Cyclin-F

2

0

High-throughput

0.559

High

281227

FANCM
Fanconi anemia group M protein

2

0

Small-scale

0.559

High

230859

ORC5
Origin recognition complex subunit 5

1

1

High-throughput

0.536

High

281177

MK03
Mitogen-activated protein kinase 3

1

1

Small-scale

0.536

High

281223

MCM10
Protein MCM10 homolog

1

2

High-throughput

0.536

High

281163

S100B
Protein S100-B

1

1

High-throughput

0.536

High

281246

TIPIN
TIMELESS-interacting protein

1

1

High-throughput

0.536

High

281264

TIM
Protein timeless homolog

1

1

High-throughput

0.536

High

281268

T22D4
TSC22 domain family protein 4

1

1

High-throughput

0.536

High

281188

CDN1A
Cyclin-dependent kinase inhibitor 1

1

0

High-throughput

0.513

High

281192

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

0

High-throughput

0.513

High

281260

ORC3
Origin recognition complex subunit 3

1

0

High-throughput

0.513

High

193737

PER1
Period circadian protein homolog 1

1

0

High-throughput

0.513

High

281162

ALBU
Albumin

1

0

High-throughput

0.513

High

281193

MAGA9
Melanoma-associated antigen 9

1

0

High-throughput

0.513

High

281197

BRCA2
Breast cancer type 2 susceptibility protein

1

0

Small-scale

0.513

High

281217

SOLH1
Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1

1

0

High-throughput

0.513

High

281231

ARI1B
AT-rich interactive domain-containing protein 1B

1

0

High-throughput

0.513

High

281240

NACC1
Nucleus accumbens-associated protein 1

1

0

High-throughput

0.513

High

281242

BCL7B
B-cell CLL/lymphoma 7 protein family member B

1

0

High-throughput

0.513

High

281253

PDS5B
Sister chromatid cohesion protein PDS5 homolog B

1

0

Small-scale

0.513

High

281269

LMBL1
Lethal(3)malignant brain tumor-like protein 1

1

0

Small-scale

0.513

High

281270

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

0

High-throughput

0.513

High

142464

IMA3
Importin subunit alpha-3

1

2

High-throughput

0.501

High

281167

DPOLA
DNA polymerase alpha catalytic subunit

1

4

Small-scale

0.501

High

221987

NCK2
Cytoplasmic protein NCK2

1

2

High-throughput

0.489

High

258680

DNJA2
DnaJ homolog subfamily A member 2

1

1

High-throughput

0.489

High

281170

CD79A
B-cell antigen receptor complex-associated protein alpha chain

1

1

High-throughput

0.489

High

281180

S10A2
Protein S100-A2

1

1

High-throughput

0.489

High

281189

CD79B
B-cell antigen receptor complex-associated protein beta chain

1

1

High-throughput

0.489

High

281196

BLK
Tyrosine-protein kinase Blk

1

1

High-throughput

0.489

High

281202

KLRB1
Killer cell lectin-like receptor subfamily B member 1

1

1

High-throughput

0.489

High

281203

KLRD1
Natural killer cells antigen CD94

1

1

High-throughput

0.489

High

281265

LAMP3
Lysosome-associated membrane glycoprotein 3

1

1

High-throughput

0.489

High

281168

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.480

High

72362

IMA8
Importin subunit alpha-8

1

2

High-throughput

0.479

High

163022

CHK1
Serine/threonine-protein kinase Chk1

1

1

Small-scale

0.479

High

281174

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

1

Small-scale

0.479

High

281175

CDK2
Cyclin-dependent kinase 2

1

1

Small-scale

0.479

High

281178

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

281195

CDK7
Cyclin-dependent kinase 7

1

1

High-throughput

0.479

High

281211

KS6A1
Ribosomal protein S6 kinase alpha-1

1

1

High-throughput

0.479

High

281212

T22D1
TSC22 domain family protein 1

1

2

High-throughput

0.479

High

281214

DUS7
Dual specificity protein phosphatase 7

1

1

High-throughput

0.479

High

281262

KS6B2
Ribosomal protein S6 kinase beta-2

1

1

High-throughput

0.479

High

281272

DUS10
Dual specificity protein phosphatase 10

1

1

High-throughput

0.479

High

281257

DONS
Protein downstream neighbor of Son

1

0

Small-scale

0.464

High

281204

ORC1
Origin recognition complex subunit 1

1

0

Small-scale

0.460

High

281205

ORC2
Origin recognition complex subunit 2

1

0

Small-scale

0.460

High

281271

ORC6
Origin recognition complex subunit 6

1

0

Small-scale

0.460

High

240282

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

259210

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.458

High

281160

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

281169

BIP
Endoplasmic reticulum chaperone BiP

1

0

High-throughput

0.458

High

281184

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

281185

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

281198

PP4C
Serine/threonine-protein phosphatase 4 catalytic subunit

1

0

High-throughput

0.458

High

281200

H31
Histone H3.1

1

0

Small-scale

0.458

High

281201

NFIA
Nuclear factor 1 A-type

1

0

High-throughput

0.458

High

281210

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.458

High

281216

ESCO2
N-acetyltransferase ESCO2

1

0

Small-scale

0.458

High

281224

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

0

High-throughput

0.458

High

281225

SHLD2
Shieldin complex subunit 2

1

0

High-throughput

0.458

High

281235

DTD1
D-aminoacyl-tRNA deacylase 1

1

0

Small-scale

0.458

High

281238

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

281241

WRIP1
ATPase WRNIP1

1

0

Small-scale

0.458

High

281247

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.458

High

281249

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

281251

SHCAF
SIN3-HDAC complex-associated factor

1

0

Small-scale

0.458

High

281254

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

0

High-throughput

0.458

High

281255

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

0

High-throughput

0.458

High

281258

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

281259

RTEL1
Regulator of telomere elongation helicase 1

1

0

Small-scale

0.458

High

281165

LCK
Tyrosine-protein kinase Lck

1

1

Small-scale

0.457

High

281191

CSK
Tyrosine-protein kinase CSK

1

2

Small-scale

0.457

High

281179

DPOD1
DNA polymerase delta catalytic subunit

1

4

Small-scale

0.445

High

281218

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.445

High

281206

SQSTM
Sequestosome-1

1

0

High-throughput

0.426

High

281199

RAB4B
Ras-related protein Rab-4B

2

0

High-throughput

0.316

High

221701

TPPC3
Trafficking protein particle complex subunit 3

1

0

High-throughput

0.282

High

281239

KCC1G
Calcium/calmodulin-dependent protein kinase type 1G

1

0

High-throughput

0.282

High

182433

GP182
G-protein coupled receptor 182

1

0

High-throughput

0.279

Low

230933

TYOBP
TYRO protein tyrosine kinase-binding protein

1

0

High-throughput

0.279

Low

260814

RAMP3
Receptor activity-modifying protein 3

1

0

High-throughput

0.279

Low

281166

TRFM
Melanotransferrin

1

0

High-throughput

0.279

Low

281172

ARSA
Arylsulfatase A

1

0

High-throughput

0.279

Low

281186

BASI
Basigin

1

0

High-throughput

0.279

Low

281187

FDFT
Squalene synthase

1

0

High-throughput

0.279

Low

281220

LYPD5
Ly6/PLAUR domain-containing protein 5

1

0

High-throughput

0.279

Low

281226

HDBP1
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

1

0

High-throughput

0.279

Low

281228

LRC25
Leucine-rich repeat-containing protein 25

1

0

High-throughput

0.279

Low

281233

F174A
Membrane protein FAM174A

1

0

High-throughput

0.279

Low

281234

HUMMR
Protein MGARP

1

0

High-throughput

0.279

Low

281245

THTPA
Thiamine-triphosphatase

1

0

High-throughput

0.279

Low

281256

MTMR4
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4

1

0

High-throughput

0.279

Low

281261

CCG4
Voltage-dependent calcium channel gamma-4 subunit

1

0

High-throughput

0.279

Low

281237

DDT4L
DNA damage-inducible transcript 4-like protein

1

0

High-throughput

0.268

Low

281156

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

281157

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

0

High-throughput

0.249

Low

281159

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.249

Low

281164

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

281171

CCL2
C-C motif chemokine 2

1

0

Small-scale

0.249

Low

281213

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

0

High-throughput

0.249

Low

281219

DCA15
DDB1- and CUL4-associated factor 15

1

0

High-throughput

0.249

Low

281221

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

High-throughput

0.249

Low

281229

FBXL6
F-box/LRR-repeat protein 6

1

0

High-throughput

0.249

Low

281230

KDF1
Keratinocyte differentiation factor 1

1

0

High-throughput

0.249

Low

281232

RIN3
Ras and Rab interactor 3

1

0

High-throughput

0.249

Low

281248

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

281252

FBX6
F-box only protein 6

1

0

High-throughput

0.249

Low

281267

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

171374

S27A2
Long-chain fatty acid transport protein 2

1

0

High-throughput

0.232

Low

281161

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

0

High-throughput

0.232

Low

281222

SV2B
Synaptic vesicle glycoprotein 2B

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025