HitPredict

Interactor 1: TOX4 (O94842)
TOX high mobility group box family member 4
Gene: TOX4

Interactor 2: TOX2 (Q96NM4)
TOX high mobility group box family member 2 (Granulosa cell HMG box protein 1) (GCX-1)
Gene: TOX2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HMG_box~HMG_box
Common GO terms	GO:0005634 - nucleus GO:0006357 - regulation of transcription by RNA polymerase II GO:0031490 - chromatin DNA binding
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 621 Hs			1 488
+	Hs
		318426 TOX4_HUMAN (1-621): 3.07e-108: 341: 100.00		TOX4_HUMAN (44-434): 3.66e-55: 196: 32.26
+	Hs
		318429 TOX4_HUMAN (1-621): 3.07e-108: 341: 100.00		NSD2_HUMAN (88-487): 5.12e-45: 171: 15.18
+	Hs
		318476 TOX4_HUMAN (1-621): 3.07e-108: 341: 100.00		SSRP1_HUMAN (181-404): 1.02e-30: 127: 18.53
+	Hs
		320921 TOX2_HUMAN (6-416): 1.71e-44: 167: 28.64		TOX_HUMAN (34-488): 9.01e-60: 206: 37.55
+	Mm
		827315 SOX6_MOUSE (31-416): 2.25e-31: 132: 13.03		TOX3_MOUSE (37-460): 1.03e-49: 180: 35.23
+	Hs
		1065480 HMGX4_HUMAN (55-335): 2.62e-40: 157: 20.41		SSRP1_HUMAN (181-404): 1.02e-30: 127: 18.53
+	Hs
		776266 SOX6_HUMAN (31-416): 8.19e-35: 142: 13.03		SOX13_HUMAN (80-398): 1.15e-35: 142: 16.05
+	Hs
		776255 SOX6_HUMAN (31-416): 8.19e-35: 142: 13.03		HM20A_HUMAN (170-361): 1.4e-33: 131: 15.27
+	Hs
		1445888 HM20A_HUMAN (133-423): 3.89e-36: 140: 16.56		HM20A_HUMAN (170-361): 1.4e-33: 131: 15.27
+	Mm
		697750 LEF1_MOUSE (29-320): 9.41e-39: 149: 12.21		TF7L2_MOUSE (46-367): 1.1e-28: 120: 10.91
+	Hs
		776235 SOX6_HUMAN (31-416): 8.19e-35: 142: 13.03		CIC_HUMAN (76-452): 4.5e-28: 120: 12.73
+	Hs
		776258 SOX6_HUMAN (31-416): 8.19e-35: 142: 13.03		HM20B_HUMAN (218-329): 1.83e-28: 116: 23.68
+	Hs
		776161 SOX6_HUMAN (31-416): 8.19e-35: 142: 13.03		SOX2_HUMAN (216-439): 3.79e-28: 115: 15.72
+	Hs
		1445897 HM20A_HUMAN (133-423): 3.89e-36: 140: 16.56		HM20B_HUMAN (218-329): 1.83e-28: 116: 23.68
+	Hs
		872767 HM20A_HUMAN (133-423): 3.89e-36: 140: 16.56		SOX2_HUMAN (216-439): 3.79e-28: 115: 15.72
+	Mm
		776027 SOX6_MOUSE (31-416): 2.25e-31: 132: 13.03		SOX5_MOUSE (85-426): 3.22e-28: 120: 13.11
+	Mm
		697737 LEF1_MOUSE (29-320): 9.41e-39: 149: 12.21		HMGB2_MOUSE (248-394): 4.04e-15: 76.2: 18.12
+	Dm
		1174467 DICH_DROME (106-299): 7.08e-33: 132: 19.29		HMG2_DROME (242-372): 1.41e-15: 80.5: 15.56