Protein: HMGX4
HMG domain-containing protein 4 (HMG box-containing protein 4) (High mobility group protein 2-like 1) (Protein HMGBCG)

Gene: HMGX4, HMGXB4
Organism: Homo sapiens
Interactions: 118
UniProt ID: Q9UGU5

Gene Ontology (top 5):
GO:0003677 - DNA binding
GO:0008333 - endosome to lysosome transport
GO:0016055 - Wnt signaling pathway
GO:0016589 - NURF complex
GO:0030178 - negative regulation of Wnt signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1459657

HMGX4
HMG domain-containing protein 4

2

20

High-throughput

0.783

High

1065480

SSRP1
FACT complex subunit SSRP1

1

19

High-throughput

0.691

High

1312702

BAP18
BPTF-associated chromatin complex component 1

4

0

High-throughput

0.657

High

1066535

RBBP4
Histone-binding protein RBBP4

2

20

High-throughput

0.628

High

911422

IMA5
Importin subunit alpha-5

1

9

High-throughput

0.618

High

243759

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

2

20

High-throughput

0.611

High

703393

SMCA1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1

2

20

High-throughput

0.611

High

297876

PIAS2
E3 SUMO-protein ligase PIAS2

2

8

High-throughput

0.606

High

1402792

STRBP
Spermatid perinuclear RNA-binding protein

2

20

High-throughput

0.606

High

981164

H2B1C
Histone H2B type 1-C/E/F/G/I

2

20

High-throughput

0.584

High

998916

H31
Histone H3.1

2

20

High-throughput

0.584

High

502166

H2AZ
Histone H2A.Z

2

20

High-throughput

0.558

High

1034627

AK17A
A-kinase anchor protein 17A

2

7

High-throughput

0.553

High

1398116

STAC3
SH3 and cysteine-rich domain-containing protein 3

2

4

High-throughput

0.553

High

1400268

LENG8
Leukocyte receptor cluster member 8

2

11

High-throughput

0.553

High

1431853

TSYL2
Testis-specific Y-encoded-like protein 2

2

7

High-throughput

0.553

High

1141345

BRD3
Bromodomain-containing protein 3

2

20

High-throughput

0.549

High

714494

PML
Protein PML

1

20

High-throughput

0.536

High

1132648

KIF22
Kinesin-like protein KIF22

1

2

High-throughput

0.536

High

1163268

H2B2E
Histone H2B type 2-E

1

20

High-throughput

0.536

High

397150

ESR1
Estrogen receptor

2

20

High-throughput

0.521

High

933961

NR1H2
Oxysterols receptor LXR-beta

1

14

High-throughput

0.508

High

250879

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

6

High-throughput

0.489

High

520717

RRAS
Ras-related protein R-Ras

1

6

High-throughput

0.489

High

848306

MAGA3
Melanoma-associated antigen 3

1

5

High-throughput

0.489

High

1029777

FOXK2
Forkhead box protein K2

1

20

High-throughput

0.489

High

1241055

L2GL2
LLGL scribble cell polarity complex component 2

1

7

High-throughput

0.489

High

1242002

DJC24
DnaJ homolog subfamily C member 24

1

6

High-throughput

0.489

High

1322806

CNTRB
Centrobin

1

7

High-throughput

0.489

High

1369544

KIFA3
Kinesin-associated protein 3

1

20

High-throughput

0.489

High

1399432

ARAP1
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1

1

12

High-throughput

0.489

High

210363

PHF1
PHD finger protein 1

1

4

High-throughput

0.479

High

282325

SAP30
Histone deacetylase complex subunit SAP30

1

2

High-throughput

0.479

High

352261

MBD3
Methyl-CpG-binding domain protein 3

1

8

High-throughput

0.479

High

373412

MYC
Myc proto-oncogene protein

1

20

High-throughput

0.479

High

406765

MYCN
N-myc proto-oncogene protein

1

19

High-throughput

0.479

High

675715

TYY1
Transcriptional repressor protein YY1

1

13

High-throughput

0.479

High

883725

CENPA
Histone H3-like centromeric protein A

1

20

High-throughput

0.479

High

905251

MECP2
Methyl-CpG-binding protein 2

1

20

High-throughput

0.479

High

980491

H4
Histone H4

1

12

High-throughput

0.479

High

1086833

BPTF
Nucleosome-remodeling factor subunit BPTF

1

20

High-throughput

0.479

High

1088602

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

20

High-throughput

0.479

High

1133029

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

20

High-throughput

0.479

High

1135285

SHPRH
E3 ubiquitin-protein ligase SHPRH

1

20

High-throughput

0.479

High

1195611

ARI4B
AT-rich interactive domain-containing protein 4B

1

20

High-throughput

0.479

High

1216637

LIN9
Protein lin-9 homolog

1

2

High-throughput

0.479

High

1335466

HJURP
Holliday junction recognition protein

1

1

High-throughput

0.479

High

1351292

CHD5
Chromodomain-helicase-DNA-binding protein 5

1

20

High-throughput

0.479

High

1403043

SIN3A
Paired amphipathic helix protein Sin3a

1

8

High-throughput

0.479

High

1454896

ZN219
Zinc finger protein 219

1

9

High-throughput

0.479

High

1458210

MBD2
Methyl-CpG-binding domain protein 2

1

8

High-throughput

0.479

High

1459196

ZRAN1
Ubiquitin thioesterase ZRANB1

1

15

High-throughput

0.479

High

1459659

MTF2
Metal-response element-binding transcription factor 2

1

4

High-throughput

0.479

High

573715

ENPL
Endoplasmin

1

8

High-throughput

0.470

High

1270733

Q7KZS0
SUMO-conjugating enzyme UBC9

1

11

High-throughput

0.470

High

1350738

CCHCR
Coiled-coil alpha-helical rod protein 1

1

5

High-throughput

0.470

High

1430134

ENKD1
Enkurin domain-containing protein 1

1

1

High-throughput

0.470

High

1152489

T22D1
TSC22 domain family protein 1

1

20

High-throughput

0.464

High

1239688

JMJD6
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

1

7

High-throughput

0.464

High

332772

EPM2A
Laforin

1

0

Small-scale

0.460

High

1253007

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

High-throughput

0.458

High

964493

SUMO2
Small ubiquitin-related modifier 2

1

15

High-throughput

0.457

High

1006778

SRPK2
SRSF protein kinase 2

1

12

High-throughput

0.457

High

1420475

DPY30
Protein dpy-30 homolog

1

1

Small-scale

0.457

High

633399

MX1
Interferon-induced GTP-binding protein Mx1

1

5

Small-scale

0.439

High

993794

UBC9
SUMO-conjugating enzyme UBC9

1

11

High-throughput

0.439

High

1207459

HABP4
Intracellular hyaluronan-binding protein 4

1

3

Small-scale

0.439

High

1368509

CBP
CREB-binding protein

1

20

Small-scale

0.439

High

260579

BRD4
Bromodomain-containing protein 4

1

20

High-throughput

0.437

High

274393

SIN3B
Paired amphipathic helix protein Sin3b

1

8

High-throughput

0.437

High

276800

TBCA
Tubulin-specific chaperone A

1

1

High-throughput

0.437

High

285510

EED
Polycomb protein EED

1

20

High-throughput

0.437

High

317025

MTA2
Metastasis-associated protein MTA2

1

20

High-throughput

0.437

High

326079

UBR5
E3 ubiquitin-protein ligase UBR5

1

15

High-throughput

0.437

High

519575

MYBB
Myb-related protein B

1

4

High-throughput

0.437

High

674364

BRD2
Bromodomain-containing protein 2

1

20

High-throughput

0.437

High

986795

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

16

High-throughput

0.437

High

1017276

H33
Histone H3.3

1

20

High-throughput

0.437

High

1094747

CAF1A
Chromatin assembly factor 1 subunit A

1

9

High-throughput

0.437

High

1094824

CAF1B
Chromatin assembly factor 1 subunit B

1

20

High-throughput

0.437

High

1097615

CBX3
Chromobox protein homolog 3

1

20

High-throughput

0.437

High

1102680

MTA1
Metastasis-associated protein MTA1

1

20

High-throughput

0.437

High

1137566

SUZ12
Polycomb protein SUZ12

1

2

High-throughput

0.437

High

1155873

EZH2
Histone-lysine N-methyltransferase EZH2

1

20

High-throughput

0.437

High

1208652

BRM1L
Breast cancer metastasis-suppressor 1-like protein

1

8

High-throughput

0.437

High

1247032

RICTR
Rapamycin-insensitive companion of mTOR

1

3

High-throughput

0.437

High

1295321

P66A
Transcriptional repressor p66-alpha

1

12

High-throughput

0.437

High

1313501

SMC5
Structural maintenance of chromosomes protein 5

1

11

High-throughput

0.437

High

1357129

ZN296
Zinc finger protein 296

1

9

High-throughput

0.437

High

1361031

P66B
Transcriptional repressor p66-beta

1

12

High-throughput

0.437

High

1368409

REQU
Zinc finger protein ubi-d4

1

20

High-throughput

0.437

High

1396146

Z512B
Zinc finger protein 512B

1

10

High-throughput

0.437

High

1398776

PWP2A
PWWP domain-containing protein 2A

1

6

High-throughput

0.437

High

1401058

PHF12
PHD finger protein 12

1

20

High-throughput

0.437

High

1413359

MTA3
Metastasis-associated protein MTA3

1

20

High-throughput

0.437

High

1429916

SP130
Histone deacetylase complex subunit SAP130

1

17

High-throughput

0.437

High

1430827

BC11A
BCL11 transcription factor A

1

9

High-throughput

0.437

High

1435867

SDS3
Sin3 histone deacetylase corepressor complex component SDS3

1

8

High-throughput

0.437

High

1452457

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

5

High-throughput

0.437

High

1459658

ZN330
Zinc finger protein 330

1

4

High-throughput

0.437

High

1162072

H31T
Histone H3.1t

1

20

High-throughput

0.408

High

95816

E5RIW3
Tubulin-specific chaperone A

1

1

High-throughput

0.407

High

1256754

NKAP1
Uncharacterized protein NKAPD1

2

0

High-throughput

0.316

High

1348986

ZCH10
Zinc finger CCHC domain-containing protein 10

2

0

High-throughput

0.316

High

1381904

TET5B
Terminal nucleotidyltransferase 5B

2

0

High-throughput

0.316

High

1420025

UBL5
Ubiquitin-like protein 5

2

0

High-throughput

0.316

High

1420623

IN80B
INO80 complex subunit B

2

0

High-throughput

0.316

High

1055994

RAD51
DNA repair protein RAD51 homolog 1

1

0

High-throughput

0.279

Low

438968

DCUP
Uroporphyrinogen decarboxylase

1

0

High-throughput

0.265

Low

568596

TNNT1
Troponin T, slow skeletal muscle

1

0

High-throughput

0.265

Low

85317

RBG10
Rab GTPase-activating protein 1-like, isoform 10

1

0

High-throughput

0.249

Low

155367

CDKA1
Cyclin-dependent kinase 2-associated protein 1

1

0

High-throughput

0.249

Low

168340

HAT1
Histone acetyltransferase type B catalytic subunit

1

0

High-throughput

0.249

Low

1198006

LIN52
Protein lin-52 homolog

1

0

High-throughput

0.249

Low

1357169

GATD1
GATA zinc finger domain-containing protein 1

1

0

High-throughput

0.249

Low

1392577

LIN37
Protein lin-37 homolog

1

0

High-throughput

0.249

Low

1208996

RBG1L
Rab GTPase-activating protein 1-like

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025