HitPredict

Interactor 1: TTC4 (O95801)
Tetratricopeptide repeat protein 4 (TPR repeat protein 4)
Gene: TTC4

Interactor 2: FKBP5 (Q13451)
Peptidyl-prolyl cis-trans isomerase FKBP5 (PPIase FKBP5) (EC 5.2.1.8) (51 kDa FK506-binding protein) (51 kDa FKBP) (FKBP-51) (54 kDa progesterone receptor-associated immunophilin) (Androgen-regulated protein 6) (FF1 antigen) (FK506-binding protein 5) (FKBP-5) (FKBP54) (p54) (HSP90-binding immunophilin) (Rotamase)
Gene: FKBP5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	35271311, 25036637
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006457 - protein folding
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 387 Hs			1 457
+	Hs
		858619 PPP5_HUMAN (63-268): 4.43e-41: 153: 16.99		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		174855 OGT1_HUMAN (55-327): 5.32e-26: 112: 12.45		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		174814 OGT1_HUMAN (55-327): 5.32e-26: 112: 12.45		FKBP4_HUMAN (1-456): 1.79e-136: 402: 54.59
+	Hs
		259983 CHIP_HUMAN (74-365): 9.58e-39: 142: 15.88		FKBP6_HUMAN (2-137): 2.27e-35: 135: 35.97
+	Hs
		1034851 FKBP5_HUMAN (10-255): 2.21e-42: 155: 17.56		FKBP8_HUMAN (25-330): 3.36e-27: 114: 19.23
+	Hs
		684691 FKBP5_HUMAN (10-255): 2.21e-42: 155: 17.56		STIP1_HUMAN (265-457): 3.91e-23: 104: 17.62
+	Hs
		684549 PPP5_HUMAN (63-268): 4.43e-41: 153: 16.99		STIP1_HUMAN (265-457): 3.91e-23: 104: 17.62
+	Hs
		685025 UN45A_HUMAN (77-278): 9.89e-37: 143: 20.00		STIP1_HUMAN (265-457): 3.91e-23: 104: 17.62
+	Hs
		684646 FKBP4_HUMAN (39-247): 3.08e-37: 141: 16.36		STIP1_HUMAN (265-457): 3.91e-23: 104: 17.62
+	Hs
		118697 STIP1_HUMAN (76-220): 8.55e-13: 71.4: 19.74		AIP_HUMAN (144-414): 1.52e-49: 173: 16.72
+	Dm
		1366835 Q9VH81_DROME (31-274): 7.3e-36: 139: 18.03		Q9VPN5_DROME (265-393): 3.01e-20: 94.9: 19.38
+	Hs
		174884 OGT1_HUMAN (55-327): 5.32e-26: 112: 12.45		FKBP8_HUMAN (25-330): 3.36e-27: 114: 19.23
+	Hs
		174661 OGT1_HUMAN (55-327): 5.32e-26: 112: 12.45		STIP1_HUMAN (265-457): 3.91e-23: 104: 17.62
+	Hs
		684975 DNJC7_HUMAN (77-207): 1.44e-26: 112: 30.53		STIP1_HUMAN (265-457): 3.91e-23: 104: 17.62
+	Hs
		1012412 TMTC1_HUMAN (12-209): 8.41e-22: 99.6: 16.08		Q0VDC6_HUMAN (151-247): 5.97e-21: 90.6: 26.73
+	Hs
		175098 OGT1_HUMAN (55-327): 5.32e-26: 112: 12.45		FKB10_HUMAN (134-285): 5.25e-13: 72.9: 20.51
+	Hs
		684432 STIP1_HUMAN (76-220): 8.55e-13: 71.4: 19.74		STIP1_HUMAN (265-457): 3.91e-23: 104: 17.62
+	Dm
		817472 Q9VPN5_DROME (71-218): 8.86e-13: 71.4: 16.67		FKB12_DROME (153-247): 2.5e-20: 87.6: 26.26