Protein: RHG35
Rho GTPase-activating protein 35 (Glucocorticoid receptor DNA-binding factor 1) (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A)

Gene: RHG35, ARHGAP35
Organism: Homo sapiens
Interactions: 90
UniProt ID: Q9NRY4

Gene Ontology (top 5):
GO:0001843 - neural tube closure
GO:0003677 - DNA binding
GO:0003924 - GTPase activity
GO:0005096 - GTPase activator activity
GO:0005525 - GTP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

962536

RHOA
Transforming protein RhoA

6

20

Small-scale

0.944

High

635752

RASA1
Ras GTPase-activating protein 1

4

17

Small-scale

0.890

High

978336

RHOB
Rho-related GTP-binding protein RhoB

3

20

High-throughput

0.817

High

988748

RAC1
Ras-related C3 botulinum toxin substrate 1

2

20

Small-scale

0.778

High

987971

GRB2
Growth factor receptor-bound protein 2

2

20

Small-scale

0.768

High

955653

CDC42
Cell division control protein 42 homolog

2

20

Small-scale

0.757

High

953698

RAC3
Ras-related C3 botulinum toxin substrate 3

2

20

High-throughput

0.754

High

962839

RND3
Rho-related GTP-binding protein RhoE

2

20

Small-scale

0.754

High

1366893

RND1
Rho-related GTP-binding protein Rho6

2

20

Small-scale

0.754

High

946461

MTPN
Myotrophin

2

8

High-throughput

0.737

High

259131

DNJA2
DnaJ homolog subfamily A member 2

1

1

High-throughput

0.691

High

909199

NEK4
Serine/threonine-protein kinase Nek4

1

5

High-throughput

0.691

High

1437905

PKHA2
Pleckstrin homology domain-containing family A member 2

1

8

High-throughput

0.691

High

424558

PAI2
Plasminogen activator inhibitor 2

2

1

High-throughput

0.628

High

126823

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.618

High

412670

NTRK1
High affinity nerve growth factor receptor

1

18

High-throughput

0.618

High

581315

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.618

High

582978

EZRI
Ezrin

1

8

High-throughput

0.618

High

891326

GSK3A
Glycogen synthase kinase-3 alpha

1

6

High-throughput

0.618

High

891817

GSK3B
Glycogen synthase kinase-3 beta

1

7

High-throughput

0.618

High

910217

RND2
Rho-related GTP-binding protein RhoN

1

20

Small-scale

0.618

High

920300

PLK1
Serine/threonine-protein kinase PLK1

1

8

High-throughput

0.618

High

953130

ACTB
Actin, cytoplasmic 1

1

20

High-throughput

0.618

High

986754

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

4

High-throughput

0.618

High

995842

ACTC
Actin, alpha cardiac muscle 1

1

19

High-throughput

0.618

High

1015831

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.618

High

1109224

PRP4K
Serine/threonine-protein kinase PRP4 homolog

1

8

High-throughput

0.618

High

1255716

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.618

High

1295579

MIB1
E3 ubiquitin-protein ligase MIB1

1

8

High-throughput

0.618

High

1433529

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.618

High

1436499

ECT2
Protein ECT2

1

14

Small-scale

0.618

High

1449003

ZO2
Tight junction protein 2

1

9

High-throughput

0.618

High

1253665

PKHG7
Pleckstrin homology domain-containing family G member 7

1

10

High-throughput

0.575

High

402802

CYTB
Cystatin-B

2

2

High-throughput

0.571

High

424463

HMGN1
Non-histone chromosomal protein HMG-14

2

2

High-throughput

0.571

High

583897

UCHL3
Ubiquitin carboxyl-terminal hydrolase isozyme L3

2

3

High-throughput

0.571

High

648239

NDKB
Nucleoside diphosphate kinase B

2

4

High-throughput

0.571

High

660175

COF1
Cofilin-1

2

3

High-throughput

0.571

High

1029560

SRSF2
Serine/arginine-rich splicing factor 2

2

5

High-throughput

0.571

High

1258318

MOB2
MOB kinase activator 2

2

2

High-throughput

0.571

High

751347

DUT
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial

2

0

High-throughput

0.547

High

212999

HS12A
Heat shock 70 kDa protein 12A

1

1

High-throughput

0.536

High

347361

BAG2
BAG family molecular chaperone regulator 2

1

4

High-throughput

0.536

High

391484

FRIL
Ferritin light chain

1

2

High-throughput

0.536

High

832812

BCL6
B-cell lymphoma 6 protein

1

20

Small-scale

0.536

High

1148064

SF3B3
Splicing factor 3B subunit 3

1

5

High-throughput

0.536

High

1449002

KLH14
Kelch-like protein 14

1

10

High-throughput

0.536

High

1449005

MCTS1
Malignant T-cell-amplified sequence 1

2

1

High-throughput

0.521

High

1449006

PA2G4
Proliferation-associated protein 2G4

1

0

High-throughput

0.513

High

239218

ZNRD2
Protein ZNRD2

1

4

High-throughput

0.489

High

1238912

CRCDL
CRACD-like protein

1

4

High-throughput

0.489

High

1398233

HS12B
Heat shock 70 kDa protein 12B

1

1

High-throughput

0.489

High

1146182

K1H1
Keratin, type I cuticular Ha1

1

6

High-throughput

0.481

High

228380

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

1

3

High-throughput

0.479

High

346385

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

7

High-throughput

0.479

High

459767

PROF1
Profilin-1

1

6

High-throughput

0.479

High

473118

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

9

High-throughput

0.479

High

613472

VINC
Vinculin

1

8

High-throughput

0.479

High

696620

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

8

High-throughput

0.479

High

732413

PRDX2
Peroxiredoxin-2

1

7

High-throughput

0.479

High

771934

CBS
Cystathionine beta-synthase

1

3

High-throughput

0.479

High

791761

SYUA
Alpha-synuclein

1

4

High-throughput

0.479

High

862489

YAP1
Transcriptional coactivator YAP1

1

15

High-throughput

0.479

High

896643

VASP
Vasodilator-stimulated phosphoprotein

1

4

High-throughput

0.479

High

905182

MECP2
Methyl-CpG-binding protein 2

1

5

High-throughput

0.479

High

1045815

TF65
Transcription factor p65

1

6

High-throughput

0.479

High

1108191

SQSTM
Sequestosome-1

1

11

High-throughput

0.479

High

1120003

CIRBP
Cold-inducible RNA-binding protein

1

3

High-throughput

0.479

High

1124733

SRC8
Src substrate cortactin

1

19

Small-scale

0.479

High

1138674

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

4

High-throughput

0.479

High

1150831

SF01
Splicing factor 1

1

3

High-throughput

0.479

High

1276842

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

3

High-throughput

0.479

High

1289650

NAA40
N-alpha-acetyltransferase 40

1

3

High-throughput

0.479

High

1333343

NHLC2
NHL repeat-containing protein 2

1

3

High-throughput

0.479

High

1360500

PSPC1
Paraspeckle component 1

1

15

High-throughput

0.479

High

1363861

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

4

High-throughput

0.479

High

1367377

ESR2
Estrogen receptor beta

1

10

High-throughput

0.479

High

1368961

GOGA1
Golgin subfamily A member 1

1

8

High-throughput

0.479

High

1432690

BOLA2
BolA-like protein 2

1

3

High-throughput

0.479

High

1449004

STML2
Stomatin-like protein 2, mitochondrial

1

3

High-throughput

0.479

High

1449007

RTRAF
RNA transcription, translation and transport factor protein

1

1

High-throughput

0.479

High

1449001

MIC19
MICOS complex subunit MIC19

1

0

High-throughput

0.458

High

1448487

DISC1
Disrupted in schizophrenia 1 protein

1

3

High-throughput

0.457

High

530434

TAU
Microtubule-associated protein tau

1

10

High-throughput

0.445

High

106709

APRIO
Alternative prion protein

1

6

High-throughput

0.437

High

769286

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.437

High

1435645

AAMDC
Mth938 domain-containing protein

1

1

High-throughput

0.437

High

1396455

F167A
Protein FAM167A

1

0

High-throughput

0.279

Low

1226537

DCA15
DDB1- and CUL4-associated factor 15

1

0

High-throughput

0.249

Low

1438620

GLOD4
Glyoxalase domain-containing protein 4

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025