HitPredict

Interactor 1: SIX6 (O95475)
Homeobox protein SIX6 (Homeodomain protein OPTX2) (Optic homeobox 2) (Sine oculis homeobox homolog 6)
Gene: SIX6

Interactor 2: TLE3 (Q04726)
Transducin-like enhancer protein 3 (Enhancer of split groucho-like protein 3) (ESG3)
Gene: TLE3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005667 - transcription regulator complex GO:0009887 - animal organ morphogenesis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 246 Hs			1 772
+	Hs
		1048103 SIX2_HUMAN (1-225): 8.27e-88: 263: 60.09		TLE3_HUMAN (1-772): 0: 597: 100.00
+	Hs
		1047977 SIX1_HUMAN (1-232): 3.1e-86: 259: 57.76		TLE3_HUMAN (1-772): 0: 597: 100.00
+	Hs
		337924 SIX6_HUMAN (1-246): 2.95e-96: 283: 100.00		TLE1_HUMAN (1-772): 0: 553: 77.96
+	Hs
		337926 SIX6_HUMAN (1-246): 2.95e-96: 283: 100.00		TLE4_HUMAN (1-772): 0: 541: 80.52
+	Hs
		333895 SIX3_HUMAN (1-246): 1.07e-88: 267: 78.35		TLE1_HUMAN (1-772): 0: 553: 77.96
+	Hs
		1047870 SIX2_HUMAN (1-225): 8.27e-88: 263: 60.09		TLE1_HUMAN (1-772): 0: 553: 77.96
+	Mm
		1224209 SIX6_MOUSE (1-246): 1.42e-91: 271: 97.97		TLE4_MOUSE (1-772): 0: 542: 80.65
+	Mm
		1223917 SIX3_MOUSE (1-246): 5.95e-89: 268: 78.35		TLE4_MOUSE (1-772): 0: 542: 80.65
+	Dm
		594692 SO_DROME (4-212): 1.2e-81: 252: 59.81		GROU_DROME (1-772): 1.44e-140: 433: 58.36
+	Dm
		594700 OPTIX_DROME (1-246): 2.29e-75: 238: 64.45		GROU_DROME (1-772): 1.44e-140: 433: 58.36
+	Hs
		337927 SIX6_HUMAN (1-246): 2.95e-96: 283: 100.00		TLE5_HUMAN (1-200): 1.39e-100: 310: 62.19
+	Mm
		988927 SIX6_MOUSE (1-246): 1.42e-91: 271: 97.97		TLE5_MOUSE (1-200): 3.52e-100: 309: 61.69
+	Hs
		333896 SIX3_HUMAN (1-246): 1.07e-88: 267: 78.35		TLE5_HUMAN (1-200): 1.39e-100: 310: 62.19
+	Mm
		988923 SIX3_MOUSE (1-246): 5.95e-89: 268: 78.35		TLE5_MOUSE (1-200): 3.52e-100: 309: 61.69
+	Hs
		1061887 SIX2_HUMAN (1-225): 8.27e-88: 263: 60.09		TLE5_HUMAN (1-200): 1.39e-100: 310: 62.19
+	Hs
		1061705 SIX1_HUMAN (1-232): 3.1e-86: 259: 57.76		TLE5_HUMAN (1-200): 1.39e-100: 310: 62.19
+	Hs
		1212331 SIX2_HUMAN (1-225): 8.27e-88: 263: 60.09		Q5T3G3_HUMAN (1-232): 5.32e-94: 294: 67.49
+	Ce
		146046 HM32_CAEEL (5-241): 3.24e-64: 208: 53.17		UNC37_CAEEL (18-686): 1.07e-81: 274: 17.53
+	Hs
		662211 PAX7_HUMAN (120-238): 9.2e-33: 126: 24.37		WDR5_HUMAN (238-560): 1.08e-30: 125: 8.46
+	Hs
		261365 PAX7_HUMAN (120-238): 9.2e-33: 126: 24.37		TBL1X_HUMAN (680-768): 3.22e-13: 75.2: 17.31