HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: CSRP1 (P21291)
Cysteine and glycine-rich protein 1 (Cysteine-rich protein 1) (CRP) (CRP1) (Epididymis luminal protein 141) (HEL-141)
Gene: CSRP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.61	0.60	0.608

Property	Details
Experiments	20029029, unassigned2173
Identification Methods	protein complementation assay, ubiquitin reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005925 - focal adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 193
+	Hs
		339091 EGFR_HUMAN (1-1210): 0: 1241: 100.00		LIMA1_HUMAN (3-117): 9.06e-21: 91: 27.83
+	Hs
		300984 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ABLM3_HUMAN (7-169): 1.17e-20: 90.5: 14.97
+	Hs
		338620 EGFR_HUMAN (1-1210): 0: 1241: 100.00		MICA3_HUMAN (3-118): 4.43e-18: 83.3: 27.94
+	Hs
		150499 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ABLM1_HUMAN (119-192): 6.1e-14: 71.2: 27.03
+	Hs
		338117 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PAXI_HUMAN (6-67): 2.97e-11: 63.1: 27.42
+	Hs
		383706 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		CRIP2_HUMAN (3-81): 6.3e-17: 77: 37.50
+	Hs
		434295 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		PDLI7_HUMAN (68-190): 3.94e-26: 105: 16.54
+	Hs
		411503 INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87		PDLI7_HUMAN (68-190): 3.94e-26: 105: 16.54
+	Rn
		88607 INSR_RAT (579-1032): 2.5e-106: 367: 23.66		D3ZGN7_RAT (3-121): 9.17e-18: 82.5: 28.10
+	Hs
		238956 FAK1_HUMAN (716-991): 1.58e-53: 206: 37.68		LPXN_HUMAN (4-128): 1.51e-22: 95.1: 15.20
+	Mm
		222881 ACK1_MOUSE (691-967): 2.4e-53: 206: 38.87		LIMA1_MOUSE (3-117): 8.96e-21: 91: 28.70
+	Mm
		222871 ACK1_MOUSE (691-967): 2.4e-53: 206: 38.87		MICA3_MOUSE (3-117): 1.15e-17: 82.1: 28.21
+	Mm
		710146 FAK1_MOUSE (716-991): 5.99e-54: 207: 37.68		PAXI_MOUSE (6-67): 2.13e-11: 63.5: 29.03
+	Hs
		823375 FAK1_HUMAN (716-991): 1.58e-53: 206: 37.68		PAXI_HUMAN (6-67): 2.97e-11: 63.1: 27.42
+	Gg
		823524 FAK1_CHICK (716-971): 5e-52: 201: 38.67		PAXI_CHICK (6-67): 3.1e-12: 66.2: 29.03
+	Hs
		200174 FAK1_HUMAN (716-991): 1.58e-53: 206: 37.68		TGFI1_HUMAN (6-67): 2.14e-10: 60.8: 27.42
+	Hs
		789046 ABL2_HUMAN (707-974): 5.53e-52: 202: 40.37		PAXI_HUMAN (6-67): 2.97e-11: 63.1: 27.42
+	Mm
		1257660 FAK2_MOUSE (716-974): 4.22e-52: 201: 37.64		PAXI_MOUSE (6-67): 2.13e-11: 63.5: 29.03
+	Mm
		710149 FAK1_MOUSE (716-991): 5.99e-54: 207: 37.68		LPXN_MOUSE (6-67): 7.37e-09: 56.2: 22.58
+	Mm
		1307900 FAK2_MOUSE (716-974): 4.22e-52: 201: 37.64		LPXN_MOUSE (6-67): 7.37e-09: 56.2: 22.58