HitPredict

Interactor 1: TLE3 (Q04726)
Transducin-like enhancer protein 3 (Enhancer of split groucho-like protein 3) (ESG3)
Gene: TLE3

Interactor 2: SIX2 (Q9NPC8)
Homeobox protein SIX2 (Sine oculis homeobox homolog 2)
Gene: SIX2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.81	0.60	0.698

Property	Details
Experiments	32296183, 28514442, 33961781, unassigned1304
Identification Methods	two hybrid, affinity chromatography technology, two hybrid prey pooling approach, two hybrid array, validated two hybrid, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005667 - transcription regulator complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 772 Hs			1 291
+	Hs
		1047977 TLE3_HUMAN (1-772): 0: 597: 100.00		SIX1_HUMAN (1-291): 2.86e-85: 259: 71.86
+	Hs
		1047870 TLE1_HUMAN (1-772): 0: 553: 77.96		SIX2_HUMAN (1-291): 8.91e-93: 278: 100.00
+	Hs
		337925 TLE3_HUMAN (1-772): 0: 597: 100.00		SIX6_HUMAN (1-238): 1.99e-71: 222: 56.61
+	Hs
		337924 TLE1_HUMAN (1-772): 0: 553: 77.96		SIX6_HUMAN (1-238): 1.99e-71: 222: 56.61
+	Hs
		333895 TLE1_HUMAN (1-772): 0: 553: 77.96		SIX3_HUMAN (1-245): 2.05e-68: 217: 57.43
+	Hs
		337926 TLE4_HUMAN (1-772): 0: 541: 80.52		SIX6_HUMAN (1-238): 1.99e-71: 222: 56.61
+	Mm
		1223917 TLE4_MOUSE (1-772): 0: 542: 80.65		SIX3_MOUSE (1-245): 1.97e-68: 217: 57.43
+	Mm
		1224209 TLE4_MOUSE (1-772): 0: 542: 80.65		SIX6_MOUSE (1-210): 9.83e-70: 217: 62.62
+	Hs
		1048135 TLE3_HUMAN (1-772): 0: 597: 100.00		LHX6_HUMAN (9-264): 2.63e-40: 145: 14.55
+	Hs
		1047836 TLE1_HUMAN (1-772): 0: 553: 77.96		LHX8_HUMAN (13-252): 9.84e-43: 151: 15.81
+	Hs
		877510 TLE1_HUMAN (1-772): 0: 553: 77.96		LHX1_HUMAN (16-291): 3.69e-42: 151: 14.87
+	Hs
		895705 TLE1_HUMAN (1-772): 0: 553: 77.96		LHX2_HUMAN (10-258): 4.75e-35: 132: 15.09
+	Dm
		594692 GROU_DROME (1-772): 1.44e-140: 433: 58.36		SO_DROME (4-256): 8.48e-72: 228: 65.23
+	Hs
		814790 TLE3_HUMAN (1-772): 0: 597: 100.00		CUX1_HUMAN (136-259): 8.98e-10: 61.3: 24.49
+	Dm
		594700 GROU_DROME (1-772): 1.44e-140: 433: 58.36		OPTIX_DROME (4-249): 8.47e-54: 183: 50.40
+	Hs
		814791 TLE4_HUMAN (1-772): 0: 541: 80.52		CUX1_HUMAN (136-259): 8.98e-10: 61.3: 24.49
+	Hs
		1061705 TLE5_HUMAN (1-200): 1.39e-100: 310: 62.19		SIX1_HUMAN (1-291): 2.86e-85: 259: 71.86
+	Hs
		337927 TLE5_HUMAN (1-200): 1.39e-100: 310: 62.19		SIX6_HUMAN (1-238): 1.99e-71: 222: 56.61
+	Hs
		333896 TLE5_HUMAN (1-200): 1.39e-100: 310: 62.19		SIX3_HUMAN (1-245): 2.05e-68: 217: 57.43
+	Hs
		895708 TLE5_HUMAN (1-200): 1.39e-100: 310: 62.19		LHX2_HUMAN (10-258): 4.75e-35: 132: 15.09