HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: IMB1 (Q14974)
Importin subunit beta-1 (Importin-90) (Karyopherin subunit beta-1) (Nuclear factor p97) (Pore targeting complex 97 kDa subunit) (PTAC97)
Gene: KPNB1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.633

Property	Details
Experiments	24797263, 23956138, 15657067
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0016020 - membrane GO:0019899 - enzyme binding GO:0031965 - nuclear membrane
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 1210 Hs			1 876
+	Hs
		383812 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		IMB1_HUMAN (1-876): 0: 635: 100.00
+	Hs
		312152 EGFR_HUMAN (1-1210): 0: 1241: 100.00		IPO7_HUMAN (3-848): 8.3e-82: 286: 12.03
+	Hs
		338800 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TNPO1_HUMAN (125-870): 3.59e-28: 123: 12.21
+	Hs
		155507 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TNPO2_HUMAN (124-869): 4.11e-25: 114: 14.04
+	Hs
		127154 EGFR_HUMAN (1-1210): 0: 1241: 100.00		IPO5_HUMAN (89-863): 6.82e-13: 75: 10.97
+	Hs
		383912 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		TNPO1_HUMAN (125-870): 3.59e-28: 123: 12.21
+	Hs
		435716 IGF1R_HUMAN (354-658): 1.12e-14: 81.4: 18.47		TNPO1_HUMAN (125-870): 3.59e-28: 123: 12.21