Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR
Interactor 2: FKBP8 (Q14318)
Peptidyl-prolyl cis-trans isomerase FKBP8 (PPIase FKBP8) (EC 5.2.1.8) (38 kDa FK506-binding protein) (38 kDa FKBP) (FKBP-38) (hFKBP38) (FK506-binding protein 8) (FKBP-8) (FKBPR38) (Rotamase)
Gene: FKBP8
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.67 | 1.00 | 0.819 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 20029029, unassigned2173 |
| Identification Methods | protein complementation assay, anti tag coimmunoprecipitation, ubiquitin reconstruction, anti bait coimmunoprecipitation |
| Interaction Type | direct interaction, physical association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | FKBP_C~PK_Tyr_Ser-Thr |
| Common GO terms | GO:0005516 - calmodulin binding GO:0005789 - endoplasmic reticulum membrane GO:0016020 - membrane GO:0032991 - protein-containing complex GO:0043066 - negative regulation of apoptotic process |
| Homologous interactions | 19 |
Homologous interactions
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
