HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: CALD1 (Q05682)
Caldesmon (CDM)
Gene: CALD1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	36736316
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005516 - calmodulin binding GO:0005886 - plasma membrane GO:0045296 - cadherin binding
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1210 Hs			1 793
+	Hs
		338508 EGFR_HUMAN (1-1210): 0: 1241: 100.00		GRDN_HUMAN (28-793): 9.97e-36: 148: 12.77
+	Hs
		338478 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ITSN1_HUMAN (235-636): 6.18e-27: 120: 21.34
+	Hs
		254427 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ROCK2_HUMAN (1-685): 2.36e-23: 108: 9.77
+	Hs
		338037 EGFR_HUMAN (1-1210): 0: 1241: 100.00		MYH9_HUMAN (2-631): 8.69e-22: 103: 10.87
+	Hs
		339058 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ITSN2_HUMAN (3-406): 4.87e-21: 101: 16.75
+	Hs
		338852 EGFR_HUMAN (1-1210): 0: 1241: 100.00		KI16B_HUMAN (113-599): 8.25e-21: 100: 15.99
+	Hs
		338442 EGFR_HUMAN (1-1210): 0: 1241: 100.00		GOGB1_HUMAN (5-752): 1.76e-17: 89.9: 10.43
+	Hs
		383838 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		GRDN_HUMAN (28-793): 9.97e-36: 148: 12.77
+	Hs
		601922 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		GOGB1_HUMAN (5-752): 1.76e-17: 89.9: 10.43
+	Hs
		411404 INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87		GRDN_HUMAN (28-793): 9.97e-36: 148: 12.77
+	Hs
		665608 EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76		ITSN1_HUMAN (235-636): 6.18e-27: 120: 21.34
+	Rn
		94275 INSR_RAT (579-1032): 2.5e-106: 367: 23.66		F1LUA1_RAT (1-679): 9.13e-33: 138: 10.53
+	Hs
		665375 EPHA3_HUMAN (654-981): 7.78e-111: 372: 34.51		MYH9_HUMAN (2-631): 8.69e-22: 103: 10.87
+	Mm
		222882 ACK1_MOUSE (691-967): 2.4e-53: 206: 38.87		MY18A_MOUSE (1-628): 2.26e-29: 128: 15.96
+	Mm
		222875 ACK1_MOUSE (691-967): 2.4e-53: 206: 38.87		MYH9_MOUSE (2-638): 2.4e-23: 108: 10.87
+	Mm
		222845 ACK1_MOUSE (691-967): 2.4e-53: 206: 38.87		MYH10_MOUSE (1-631): 1.18e-22: 106: 9.40