HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: PTN11 (Q06124)
Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3)
Gene: PTPN11

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.95 1.00 0.980

The method score is based on:

Property Details
Experiments 7588774, 12270932, 28065597, 20473329, 8959326, 16729043, 22973453, 7673163, 35384245, 9756944, 16273093, 24935154
Identification Methods affinity chromatography technology, two hybrid, enzymatic study, pull down, proximity labelling technology, unspecified method, anti tag coimmunoprecipitation, protein array, ubiquitin reconstruction, phosphatase assay and 1 others

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Interaction Type physical association, direct interaction, dephosphorylation reaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~Y_phosphatase
Common GO terms GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0007173 - epidermal growth factor receptor signaling pathway
GO:0019901 - protein kinase binding
GO:0032991 - protein-containing complex
and 3 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

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Hs

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Last updated: 15 Jul 2024