HitPredict

Interactor 1: CBX7 (O95931)
Chromobox protein homolog 7
Gene: CBX7

Interactor 2: PHC3 (Q8NDX5)
Polyhomeotic-like protein 3 (Early development regulatory protein 3) (Homolog of polyhomeotic 3) (hPH3)
Gene: PHC3

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.86	0.60	0.722

Property	Details
Experiments	27705803, 26186194, 28514442, 24981860, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0031519 - PcG protein complex GO:0035102 - PRC1 complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 251 Hs			1 983
+	Hs
		129773 CBX4_HUMAN (1-242): 2.25e-55: 187: 33.60		PHC3_HUMAN (1-983): 7.95e-87: 301: 100.00
+	Hs
		1132218 CBX2_HUMAN (2-216): 1.06e-38: 142: 26.05		PHC3_HUMAN (1-983): 7.95e-87: 301: 100.00
+	Hs
		351380 CBX7_HUMAN (1-251): 1.06e-81: 247: 100.00		PHC1_HUMAN (12-983): 3.36e-35: 147: 22.94
+	Hs
		129787 CBX4_HUMAN (1-242): 2.25e-55: 187: 33.60		SCMH1_HUMAN (553-982): 7e-39: 156: 17.65
+	Hs
		351395 CBX7_HUMAN (1-251): 1.06e-81: 247: 100.00		PHC2_HUMAN (30-560): 1.94e-17: 89.7: 28.52
+	Hs
		129713 CBX4_HUMAN (1-242): 2.25e-55: 187: 33.60		PHC1_HUMAN (12-983): 3.36e-35: 147: 22.94
+	Hs
		129830 CBX4_HUMAN (1-242): 2.25e-55: 187: 33.60		SCML2_HUMAN (553-982): 3.27e-33: 139: 17.40
+	Hs
		129826 CBX4_HUMAN (1-242): 2.25e-55: 187: 33.60		SCML1_HUMAN (799-982): 6.56e-33: 132: 22.28
+	Hs
		1132224 CBX2_HUMAN (2-216): 1.06e-38: 142: 26.05		SCMH1_HUMAN (553-982): 7e-39: 156: 17.65
+	Hs
		1006845 CBX2_HUMAN (2-216): 1.06e-38: 142: 26.05		PHC1_HUMAN (12-983): 3.36e-35: 147: 22.94
+	Hs
		1097636 CBX3_HUMAN (9-157): 2.46e-42: 144: 22.00		SCML2_HUMAN (553-982): 3.27e-33: 139: 17.40
+	Hs
		1132248 CBX2_HUMAN (2-216): 1.06e-38: 142: 26.05		SCML2_HUMAN (553-982): 3.27e-33: 139: 17.40
+	Hs
		129763 CBX4_HUMAN (1-242): 2.25e-55: 187: 33.60		PHC2_HUMAN (30-560): 1.94e-17: 89.7: 28.52
+	Dr
		1281818 Q804D1_DANRE (1-175): 1.65e-41: 149: 35.75		PHC2_DANRE (172-983): 3.92e-29: 127: 22.98
+	Hs
		1132246 CBX2_HUMAN (2-216): 1.06e-38: 142: 26.05		SCML1_HUMAN (799-982): 6.56e-33: 132: 22.28
+	Hs
		1097295 CBX3_HUMAN (9-157): 2.46e-42: 144: 22.00		MDC1_HUMAN (46-905): 2.05e-19: 96.6: 8.11
+	Hs
		1129590 CBX2_HUMAN (2-216): 1.06e-38: 142: 26.05		MDC1_HUMAN (46-905): 2.05e-19: 96.6: 8.11
+	Hs
		1132211 CBX2_HUMAN (2-216): 1.06e-38: 142: 26.05		PHC2_HUMAN (30-560): 1.94e-17: 89.7: 28.52
+	Mm
		1298609 Q9DCC5_MOUSE (9-157): 2.46e-42: 144: 22.00		ADNP2_MOUSE (285-699): 2.19e-12: 73.5: 21.34
+	Dm
		1479069 Q9W396_DROME (10-156): 1.06e-40: 141: 24.34		SMBT_DROME (899-981): 3.55e-12: 72.7: 34.94