HitPredict

Interactor 1: CPSF4 (O95639)
Cleavage and polyadenylation specificity factor subunit 4 (Cleavage and polyadenylation specificity factor 30 kDa subunit) (CPSF 30 kDa subunit) (NS1 effector domain-binding protein 1) (Neb-1) (No arches homolog)
Gene: CPSF4

Interactor 2: SRSF4 (Q08170)
Serine/arginine-rich splicing factor 4 (Pre-mRNA-splicing factor SRP75) (SRP001LB) (Splicing factor, arginine/serine-rich 4)
Gene: SRSF4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RRM_1~zf-CCCH
Common GO terms	GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0006397 - mRNA processing
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 269 Hs			1 494
+	Hs
		1061048 ZC3H3_HUMAN (31-226): 5.86e-38: 143: 25.50		SRSF1_HUMAN (3-166): 2.37e-57: 192: 41.42
+	Hs
		1099152 ZC3H3_HUMAN (31-226): 5.86e-38: 143: 25.50		SRSF5_HUMAN (3-256): 1.26e-49: 172: 53.85
+	Hs
		272923 ZC11A_HUMAN (62-232): 3.97e-30: 120: 16.38		SRSF6_HUMAN (1-180): 4.54e-52: 181: 78.50
+	Hs
		1099398 ZC3HE_HUMAN (61-186): 1.77e-21: 95.4: 22.37		SRSF6_HUMAN (1-180): 4.54e-52: 181: 78.50
+	Sp
		1008989 YTH1_SCHPO (65-173): 2.57e-32: 118: 54.96		SRP2_SCHPO (3-345): 2.26e-43: 158: 31.55
+	Hs
		1062018 ZC3HE_HUMAN (61-186): 1.77e-21: 95.4: 22.37		SRSF4_HUMAN (1-468): 4.58e-48: 174: 100.00
+	Hs
		1313146 ZC3H3_HUMAN (31-226): 5.86e-38: 143: 25.50		PABP3_HUMAN (3-189): 9.41e-29: 122: 19.19
+	Hs
		1061055 ZC3H8_HUMAN (86-187): 3.85e-14: 72.7: 22.12		SRSF1_HUMAN (3-166): 2.37e-57: 192: 41.42
+	Hs
		1062082 ZC3HA_HUMAN (66-166): 6.44e-20: 90.3: 25.00		SRSF4_HUMAN (1-468): 4.58e-48: 174: 100.00
+	Hs
		1099206 ZC3HA_HUMAN (66-166): 6.44e-20: 90.3: 25.00		SRSF5_HUMAN (3-256): 1.26e-49: 172: 53.85
+	Hs
		550506 MKRN1_HUMAN (36-257): 4.43e-35: 133: 16.79		PABP1_HUMAN (1-189): 3.74e-31: 128: 19.50
+	Hs
		1099435 ZC3H8_HUMAN (86-187): 3.85e-14: 72.7: 22.12		SRSF6_HUMAN (1-180): 4.54e-52: 181: 78.50
+	Hs
		272872 ZC11A_HUMAN (62-232): 3.97e-30: 120: 16.38		PABP1_HUMAN (1-189): 3.74e-31: 128: 19.50
+	Hs
		1099159 ZC3H8_HUMAN (86-187): 3.85e-14: 72.7: 22.12		SRSF5_HUMAN (3-256): 1.26e-49: 172: 53.85
+	Hs
		1102014 ZC3H3_HUMAN (31-226): 5.86e-38: 143: 25.50		PABP4_HUMAN (101-185): 3.05e-11: 67.7: 20.00
+	Hs
		1102126 MKRN1_HUMAN (36-257): 4.43e-35: 133: 16.79		PABP4_HUMAN (101-185): 3.05e-11: 67.7: 20.00
+	Hs
		1029048 MKRN1_HUMAN (36-257): 4.43e-35: 133: 16.79		TIAR_HUMAN (96-188): 1.12e-09: 61.9: 16.67
+	Hs
		550458 MKRN2_HUMAN (62-118): 6.89e-09: 58: 27.59		PABP1_HUMAN (1-189): 3.74e-31: 128: 19.50
+	Hs
		1409877 ZC3H4_HUMAN (85-233): 1.1e-19: 90.4: 18.67		RBM4B_HUMAN (3-104): 4.7e-11: 66.1: 23.08
+	Hs
		1395805 ZC3HA_HUMAN (66-166): 6.44e-20: 90.3: 25.00		RBM4B_HUMAN (3-104): 4.7e-11: 66.1: 23.08