Protein: ZC3H8
Zinc finger CCCH domain-containing protein 8

Gene: ZC3H8
Organism: Homo sapiens
Interactions: 82
UniProt ID: Q8N5P1

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000791 - euchromatin
GO:0001162 - RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0003723 - RNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1194216

LARP7
La-related protein 7

6

20

High-throughput

0.940

High

1328338

ZCRB1
Zinc finger CCHC-type and RNA-binding motif-containing protein 1

4

17

High-throughput

0.892

High

1313095

ZC3H3
Zinc finger CCCH domain-containing protein 3

2

2

High-throughput

0.789

High

1009252

PRR3
Proline-rich protein 3

2

2

High-throughput

0.776

High

250707

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

11

High-throughput

0.691

High

1061055

SRSF1
Serine/arginine-rich splicing factor 1

1

20

High-throughput

0.691

High

1099159

SRSF5
Serine/arginine-rich splicing factor 5

1

20

High-throughput

0.691

High

1099435

SRSF6
Serine/arginine-rich splicing factor 6

1

20

High-throughput

0.691

High

1148729

RBMS2
RNA-binding motif, single-stranded-interacting protein 2

1

20

High-throughput

0.691

High

1037269

H11
Histone H1.1

4

8

High-throughput

0.691

High

1328357

RL26L
Ribosomal protein uL24-like

3

4

High-throughput

0.656

High

1328349

THUM1
THUMP domain-containing protein 1

3

0

High-throughput

0.638

High

649367

H1T
Histone H1t

2

8

High-throughput

0.628

High

687458

PTBP1
Polypyrimidine tract-binding protein 1

1

14

High-throughput

0.621

High

472890

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

20

High-throughput

0.618

High

1105341

SF3B2
Splicing factor 3B subunit 2

1

1

High-throughput

0.618

High

1245390

ZC3HE
Zinc finger CCCH domain-containing protein 14

1

2

High-throughput

0.618

High

969308

RS8
Small ribosomal subunit protein eS8

2

1

High-throughput

0.611

High

1328344

CH033
UPF0488 protein C8orf33

3

1

High-throughput

0.609

High

1328350

TBA8
Tubulin alpha-8 chain

3

1

High-throughput

0.609

High

1226631

E4F1
Transcription factor E4F1

2

0

High-throughput

0.602

High

191709

MAGB2
Melanoma-associated antigen B2

2

3

High-throughput

0.601

High

301120

RL1D1
Ribosomal L1 domain-containing protein 1

2

4

High-throughput

0.601

High

860837

RS10
Small ribosomal subunit protein eS10

2

2

High-throughput

0.601

High

1112086

KRR1
KRR1 small subunit processome component homolog

2

2

High-throughput

0.601

High

1252464

LN28B
Protein lin-28 homolog B

2

15

High-throughput

0.601

High

1328345

LN28A
Protein lin-28 homolog A

2

15

High-throughput

0.601

High

372578

MYC
Myc proto-oncogene protein

2

10

High-throughput

0.584

High

911639

NCBP2
Nuclear cap-binding protein subunit 2

1

19

High-throughput

0.575

High

935423

FGF8
Fibroblast growth factor 8

2

1

High-throughput

0.574

High

997859

CSK21
Casein kinase II subunit alpha

1

5

High-throughput

0.550

High

419083

H2A1B
Histone H2A type 1-B/E

1

5

High-throughput

0.536

High

476752

RSSA
Small ribosomal subunit protein uS2

1

2

High-throughput

0.536

High

502435

H2A1
Histone H2A type 1

1

5

High-throughput

0.536

High

521810

H14
Histone H1.4

1

8

High-throughput

0.536

High

586783

RS2
Small ribosomal subunit protein uS5

1

2

High-throughput

0.536

High

612700

RL7
Large ribosomal subunit protein uL30

1

1

High-throughput

0.536

High

615869

RL17
Large ribosomal subunit protein uL22

1

1

High-throughput

0.536

High

658273

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.536

High

809725

RS19
Small ribosomal subunit protein eS19

1

1

High-throughput

0.536

High

842440

RL35
Large ribosomal subunit protein uL29

1

1

High-throughput

0.536

High

860269

RS9
Small ribosomal subunit protein uS4

1

1

High-throughput

0.536

High

969976

RS16
Small ribosomal subunit protein uS9

1

1

High-throughput

0.536

High

978607

RL23A
Large ribosomal subunit protein uL23

1

3

High-throughput

0.536

High

984851

RL31
Large ribosomal subunit protein eL31

1

1

High-throughput

0.536

High

994659

YBOX1
Y-box-binding protein 1

1

14

High-throughput

0.536

High

1252625

ZN574
Zinc finger protein 574

1

1

High-throughput

0.536

High

1328339

ZN653
Zinc finger protein 653

1

1

High-throughput

0.536

High

1328343

REXO4
RNA exonuclease 4

1

2

High-throughput

0.536

High

1328346

DDX21
Nucleolar RNA helicase 2

1

7

High-throughput

0.536

High

1328348

LYAR
Cell growth-regulating nucleolar protein

1

1

High-throughput

0.536

High

1328351

H2AW
Core histone macro-H2A.2

1

6

High-throughput

0.536

High

1328354

ZN346
Zinc finger protein 346

1

3

High-throughput

0.536

High

1328355

ABT1
Activator of basal transcription 1

1

2

High-throughput

0.536

High

1328358

YBOX2
Y-box-binding protein 2

1

14

High-throughput

0.536

High

1161940

H31T
Histone H3.1t

1

2

High-throughput

0.515

High

1328341

NLRP3
NACHT, LRR and PYD domains-containing protein 3

1

0

High-throughput

0.513

High

240153

FGF17
Fibroblast growth factor 17

1

1

High-throughput

0.489

High

315773

RECQ4
ATP-dependent DNA helicase Q4

1

6

High-throughput

0.479

High

406391

MYCN
N-myc proto-oncogene protein

1

10

High-throughput

0.479

High

504926

H2AB2
Histone H2A-Bbd type 2/3

1

6

High-throughput

0.479

High

904930

MECP2
Methyl-CpG-binding protein 2

1

3

High-throughput

0.479

High

960172

RL26
Large ribosomal subunit protein uL24

1

4

High-throughput

0.479

High

979987

H4
Histone H4

1

3

High-throughput

0.479

High

1113690

CUL3
Cullin-3

1

3

High-throughput

0.479

High

1328352

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

1328353

XPO7
Exportin-7

1

5

High-throughput

0.479

High

1328356

FZR1
Fizzy-related protein homolog

1

4

High-throughput

0.479

High

1328359

MAFB
Transcription factor MafB

1

1

High-throughput

0.479

High

485684

RU2A
U2 small nuclear ribonucleoprotein A'

1

1

High-throughput

0.445

High

810218

RL3
Large ribosomal subunit protein uL3

1

2

High-throughput

0.445

High

1139963

RRS1
Ribosome biogenesis regulatory protein homolog

1

3

High-throughput

0.445

High

1328334

RNF10
E3 ubiquitin-protein ligase RNF10

1

2

High-throughput

0.445

High

1328335

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.445

High

1328337

SRFB1
Serum response factor-binding protein 1

1

1

High-throughput

0.445

High

1328347

ABC3C
DNA dC->dU-editing enzyme APOBEC-3C

1

15

High-throughput

0.445

High

1132393

CASP8
Caspase-8

1

0

High-throughput

0.426

High

1315229

CA174
UPF0688 protein C1orf174

1

0

High-throughput

0.426

High

1328340

ZN764
Zinc finger protein 764

1

0

High-throughput

0.426

High

1328342

PYM1
Partner of Y14 and mago

1

0

High-throughput

0.426

High

1146044

K1H1
Keratin, type I cuticular Ha1

1

0

High-throughput

0.251

Low

1328336

MOT11
Monocarboxylate transporter 11

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025