HitPredict

Interactor 1: TIMP1 (P01033)
Metalloproteinase inhibitor 1 (Erythroid-potentiating activity) (EPA) (Fibroblast collagenase inhibitor) (Collagenase inhibitor) (Tissue inhibitor of metalloproteinases 1) (TIMP-1)
Gene: TIMP1

Interactor 2: MMP14 (P50281)
Matrix metalloproteinase-14 (MMP-14) (EC 3.4.24.80) (MMP-X1) (Membrane-type matrix metalloproteinase 1) (MT-MMP 1) (MTMMP1) (Membrane-type-1 matrix metalloproteinase) (MT1-MMP) (MT1MMP)
Gene: MMP14

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	1.00	0.834

Property	Details
Experiments	8804434, 26264872, 32814053
Identification Methods	pull down, affinity chromatography technology, luminescence based mammalian interactome mapping
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Hemopexin~TIMP, Peptidase_M10~TIMP
Common GO terms	GO:0005615 - extracellular space GO:0008270 - zinc ion binding GO:0031012 - extracellular matrix
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 207 Hs			1 582
+	Hs
		838537 TIMP4_HUMAN (17-199): 2.91e-92: 270: 34.92		MMP14_HUMAN (1-582): 0: 768: 100.00
+	Hs
		726505 TIMP3_HUMAN (10-199): 5.9e-87: 257: 38.97		MMP14_HUMAN (1-582): 0: 768: 100.00
+	Hs
		554808 TIMP2_HUMAN (20-199): 3.71e-82: 245: 40.96		MMP14_HUMAN (1-582): 0: 768: 100.00
+	Hs
		554810 TIMP2_HUMAN (20-199): 3.71e-82: 245: 40.96		MMP16_HUMAN (33-582): 0: 759: 55.46
+	Hs
		554809 TIMP2_HUMAN (20-199): 3.71e-82: 245: 40.96		MMP15_HUMAN (27-582): 0: 685: 52.48
+	Hs
		344781 TIMP1_HUMAN (1-207): 5.49e-112: 320: 100.00		MMP3_HUMAN (11-508): 0: 580: 35.77
+	Hs
		344777 TIMP1_HUMAN (1-207): 5.49e-112: 320: 100.00		MMP1_HUMAN (16-508): 0: 567: 35.34
+	Hs
		344784 TIMP1_HUMAN (1-207): 5.49e-112: 320: 100.00		MMP10_HUMAN (11-508): 0: 565: 35.32
+	Hs
		439275 TIMP4_HUMAN (17-199): 2.91e-92: 270: 34.92		MMP3_HUMAN (11-508): 0: 580: 35.77
+	Hs
		372742 TIMP4_HUMAN (17-199): 2.91e-92: 270: 34.92		MMP1_HUMAN (16-508): 0: 567: 35.34
+	Hs
		439265 TIMP3_HUMAN (10-199): 5.9e-87: 257: 38.97		MMP3_HUMAN (11-508): 0: 580: 35.77
+	Hs
		439263 TIMP2_HUMAN (20-199): 3.71e-82: 245: 40.96		MMP3_HUMAN (11-508): 0: 580: 35.77
+	Hs
		372726 TIMP2_HUMAN (20-199): 3.71e-82: 245: 40.96		MMP1_HUMAN (16-508): 0: 567: 35.34
+	Mm
		706099 TIMP3_MOUSE (10-199): 6.2e-84: 249: 38.46		MMP13_MOUSE (10-504): 0: 561: 32.81
+	Hs
		344780 TIMP1_HUMAN (1-207): 5.49e-112: 320: 100.00		MMP2_HUMAN (4-226): 4.4e-79: 264: 34.78
+	Hs
		344786 TIMP1_HUMAN (1-207): 5.49e-112: 320: 100.00		MMP9_HUMAN (4-224): 6.56e-65: 227: 36.20
+	Hs
		439254 TIMP4_HUMAN (17-199): 2.91e-92: 270: 34.92		MMP2_HUMAN (4-226): 4.4e-79: 264: 34.78
+	Hs
		439230 TIMP3_HUMAN (10-199): 5.9e-87: 257: 38.97		MMP2_HUMAN (4-226): 4.4e-79: 264: 34.78
+	Hs
		439223 TIMP2_HUMAN (20-199): 3.71e-82: 245: 40.96		MMP2_HUMAN (4-226): 4.4e-79: 264: 34.78
+	Hs
		540409 TIMP2_HUMAN (20-199): 3.71e-82: 245: 40.96		MMP9_HUMAN (4-224): 6.56e-65: 227: 36.20