HitPredict - High confidence protein-protein interactions

Interactor 1: AIFM1 (O95831)
Apoptosis-inducing factor 1, mitochondrial (EC 1.6.99.-) (Programmed cell death protein 8)
Gene: AIFM1

Interactor 2: AIFM1 (O95831)
Apoptosis-inducing factor 1, mitochondrial (EC 1.6.99.-) (Programmed cell death protein 8)
Gene: AIFM1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	1.00	0.915

Property	Details
Experiments	29568061, 24914854, 26535916, 20111043, 17094969
Identification Methods	proximity labelling technology, affinity chromatography technology, x-ray crystallography, biochemical, pull down, anti tag coimmunoprecipitation, two hybrid array
Interaction Type	physical association, association, direct interaction

Property	Details
Interacting Pfam domains	AIF_C~AIF_C, AIF_C~Pyr_redox_2, Pyr_redox_2~Pyr_redox_2
Common GO terms	GO:0002931 - response to ischemia GO:0003677 - DNA binding GO:0003954 - NADH dehydrogenase activity GO:0005634 - nucleus GO:0005737 - cytoplasm and 26 others more... GO:0005739 - mitochondrion GO:0005743 - mitochondrial inner membrane GO:0005758 - mitochondrial intermembrane space GO:0005829 - cytosol GO:0006915 - apoptotic process GO:0009636 - response to toxic substance GO:0016174 - NAD(P)H oxidase H2O2-forming activity GO:0016651 - oxidoreductase activity, acting on NAD(P)H GO:0030182 - neuron differentiation GO:0033108 - mitochondrial respiratory chain complex assembly GO:0043065 - positive regulation of apoptotic process GO:0043525 - positive regulation of neuron apoptotic process GO:0045041 - protein import into mitochondrial intermembrane space GO:0046983 - protein dimerization activity GO:0048471 - perinuclear region of cytoplasm GO:0060545 - positive regulation of necroptotic process GO:0070059 - intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070301 - cellular response to hydrogen peroxide GO:0071392 - cellular response to estradiol stimulus GO:0071456 - cellular response to hypoxia GO:0071732 - cellular response to nitric oxide GO:0071949 - FAD binding GO:0072572 - poly-ADP-D-ribose binding GO:0160203 - mitochondrial disulfide relay system GO:1902065 - response to L-glutamate GO:1904045 - cellular response to aldosterone
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1	613
Hs

1	613

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Last updated: 11Aug2025