HitPredict

Interactor 1: PAK4 (O96013)
Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4)
Gene: PAK4

Interactor 2: LATS2 (Q9NRM7)
Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Kinase phosphorylated during mitosis protein) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Warts-like kinase)
Gene: LATS2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	24255178
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PBD~Pkinase, Pkinase~Pkinase, Pkinase~Pkinase_C
Common GO terms	GO:0004674 - protein serine/threonine kinase activity GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0035556 - intracellular signal transduction and 1 others more... GO:0106310 - protein serine kinase activity
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 591 Hs			1 1088
+	Hs
		1097749 STK3_HUMAN (289-588): 1.9e-123: 374: 35.43		LATS2_HUMAN (1-1088): 0: 990: 100.00
+	Hs
		1093191 STK4_HUMAN (298-588): 1.62e-122: 372: 35.50		LATS2_HUMAN (1-1088): 0: 990: 100.00
+	Mm
		1274632 STK4_MOUSE (298-588): 4.38e-123: 373: 35.50		LATS2_MOUSE (1-1088): 0: 884: 80.48
+	Hs
		1448696 STK26_HUMAN (315-574): 2.22e-52: 186: 38.31		LATS2_HUMAN (1-1088): 0: 990: 100.00
+	Hs
		349061 STK3_HUMAN (289-588): 1.9e-123: 374: 35.43		LATS1_HUMAN (1-1083): 0: 731: 49.57
+	Hs
		349058 STK4_HUMAN (298-588): 1.62e-122: 372: 35.50		LATS1_HUMAN (1-1083): 0: 731: 49.57
+	Mm
		1297595 STK4_MOUSE (298-588): 4.38e-123: 373: 35.50		LATS1_MOUSE (1-1082): 0: 729: 49.91
+	Hs
		354700 PAK4_HUMAN (1-591): 0: 598: 100.00		STK38_HUMAN (583-1065): 9.36e-148: 451: 40.58
+	Sc
		924419 STE20_YEAST (11-591): 1.42e-148: 453: 31.62		CBK1_YEAST (347-1051): 1.18e-143: 451: 29.56
+	Hs
		728050 AKT2_HUMAN (261-572): 4.73e-126: 381: 23.77		AKT1_HUMAN (532-1043): 7.82e-142: 436: 22.16
+	Hs
		728630 AKT2_HUMAN (261-572): 4.73e-126: 381: 23.77		AKT3_HUMAN (532-1043): 1.17e-141: 436: 21.90
+	Hs
		728208 STK3_HUMAN (289-588): 1.9e-123: 374: 35.43		AKT1_HUMAN (532-1043): 7.82e-142: 436: 22.16
+	Hs
		728203 STK4_HUMAN (298-588): 1.62e-122: 372: 35.50		AKT1_HUMAN (532-1043): 7.82e-142: 436: 22.16
+	Hs
		728252 KS6A1_HUMAN (274-583): 3.9e-111: 350: 24.32		AKT1_HUMAN (532-1043): 7.82e-142: 436: 22.16
+	Hs
		908080 KS6A3_HUMAN (263-591): 2.97e-114: 358: 24.13		KS6A3_HUMAN (519-990): 6.36e-81: 282: 19.63
+	Mm
		616112 KS6A3_MOUSE (263-591): 3.2e-114: 358: 24.13		KS6A3_MOUSE (519-990): 7.16e-81: 281: 19.63
+	Hs
		908115 KS6A3_HUMAN (263-591): 2.97e-114: 358: 24.13		KS6A1_HUMAN (519-977): 1.35e-79: 278: 20.34
+	Hs
		1148333 KS6A1_HUMAN (274-583): 3.9e-111: 350: 24.32		KS6A1_HUMAN (519-977): 1.35e-79: 278: 20.34
+	Hs
		270786 KS6A3_HUMAN (263-591): 2.97e-114: 358: 24.13		ROCK2_HUMAN (640-1008): 6.35e-67: 248: 36.90