HitPredict

Interactor 1: NSD2 (O96028)
Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.357) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (Protein trithorax-5) (Wolf-Hirschhorn syndrome candidate 1 protein)
Gene: NSD2

Interactor 2: MECP2 (P51608)
Methyl-CpG-binding protein 2 (MeCp-2 protein) (MeCp2)
Gene: MECP2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	31248990, 38697112
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 1365 Hs			1 486
+	Hs
		905111 NSD3_HUMAN (116-1340): 0: 764: 45.27		MECP2_HUMAN (1-486): 5.18e-113: 344: 100.00
+	Hs
		216400 SUV91_HUMAN (830-1202): 3.1e-74: 255: 20.52		MECP2_HUMAN (1-486): 5.18e-113: 344: 100.00
+	Hs
		904769 EZH2_HUMAN (904-1188): 5.22e-59: 220: 22.48		MECP2_HUMAN (1-486): 5.18e-113: 344: 100.00
+	Hs
		904991 EZH1_HUMAN (932-1188): 1.1e-57: 216: 24.07		MECP2_HUMAN (1-486): 5.18e-113: 344: 100.00
+	Hs
		905153 EHMT1_HUMAN (906-1224): 5.89e-56: 215: 21.43		MECP2_HUMAN (1-486): 5.18e-113: 344: 100.00
+	Hs
		905110 SETD2_HUMAN (852-1238): 1.68e-54: 212: 27.74		MECP2_HUMAN (1-486): 5.18e-113: 344: 100.00
+	Hs
		905043 NSD1_HUMAN (69-658): 8.18e-26: 118: 14.33		MECP2_HUMAN (1-486): 5.18e-113: 344: 100.00
+	Hs
		216357 SUV91_HUMAN (830-1202): 3.1e-74: 255: 20.52		MBD4_HUMAN (99-480): 9.43e-45: 167: 20.05
+	Hs
		216558 SUV91_HUMAN (830-1202): 3.1e-74: 255: 20.52		MBD1_HUMAN (95-220): 7.01e-31: 127: 31.78
+	Hs
		352149 EZH2_HUMAN (904-1188): 5.22e-59: 220: 22.48		MBD3_HUMAN (93-249): 3.07e-43: 156: 26.88
+	Mm
		1491905 EHMT2_MOUSE (889-1199): 2.83e-54: 210: 20.65		MBD3_MOUSE (93-249): 2.36e-44: 159: 26.25
+	Hs
		352225 EHMT2_HUMAN (889-1199): 6.02e-55: 212: 20.65		MBD3_HUMAN (93-249): 3.07e-43: 156: 26.88
+	Hs
		1155855 EZH2_HUMAN (904-1188): 5.22e-59: 220: 22.48		MBD2_HUMAN (75-249): 3.33e-38: 146: 28.65
+	Hs
		352111 KMT2A_HUMAN (1049-1203): 7.33e-42: 171: 32.05		MBD3_HUMAN (93-249): 3.07e-43: 156: 26.88
+	Hs
		1041568 KMT2A_HUMAN (1049-1203): 7.33e-42: 171: 32.05		TITIN_HUMAN (240-472): 1.29e-12: 72.8: 19.57