HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.991

The method score is based on:

Property Details
Experiments 20211985, 18803307, 8665853, 9461599, 7797556, 1346931, 11526509, 30898150, 25898135, 19060928, 17486068, 39499777, 24189400, 25315821, 7531698, 32669362, 16207817, 17307140, 11408594, 21044682 and 8 others

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Identification Methods affinity chromatography technology, pull down, unspecified method, protein complementation assay, proximity labelling technology, two hybrid, anti bait coimmunoprecipitation, beta galactosidase complementation, protein kinase assay, tandem affinity purification and 1 others

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Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Furin-like~Furin-like, Furin-like~GF_recep_IV, Furin-like~Recep_L_domain, GF_recep_IV~GF_recep_IV, GF_recep_IV~Recep_L_domain, PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr, Recep_L_domain~Recep_L_domain, TM_ErbB1~TM_ErbB1
Common GO terms GO:0004713 - protein tyrosine kinase activity
GO:0004714 - transmembrane receptor protein tyrosine kinase activity
GO:0004888 - transmembrane signaling receptor activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
and 20 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 1210
Hs

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Last updated: 11Aug2025