HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: SH3G3 (Q99963)
Endophilin-A3 (EEN-B2) (Endophilin-3) (SH3 domain protein 2C) (SH3 domain-containing GRB2-like protein 3)
Gene: SH3GL3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.843

Property	Details
Experiments	25402006, 24658140, unassigned2173
Identification Methods	two hybrid, protein complementation assay, ubiquitin reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005737 - cytoplasm GO:0007165 - signal transduction GO:0031901 - early endosome membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 347
+	Hs
		363777 EGFR_HUMAN (1-1210): 0: 1246: 100.00		SH3G2_HUMAN (1-347): 1.33e-86: 266: 65.91
+	Hs
		363280 EGFR_HUMAN (1-1210): 0: 1246: 100.00		SRC8_HUMAN (7-343): 2.87e-51: 180: 14.49
+	Hs
		364024 EGFR_HUMAN (1-1210): 0: 1246: 100.00		PACN2_HUMAN (1-343): 7.13e-39: 145: 16.45
+	Mm
		1030069 EGFR_MOUSE (1-1210): 0: 1267: 90.35		GRB2_MOUSE (292-346): 1.09e-11: 65.5: 42.86
+	Hs
		363810 EGFR_HUMAN (1-1210): 0: 1246: 100.00		SRBS1_HUMAN (169-342): 1.17e-13: 74.1: 17.65
+	Rn
		988078 Q9QX70_RAT (1-1210): 0: 1250: 90.34		GRB2_RAT (290-346): 9.97e-12: 65.5: 41.38
+	Hs
		363501 EGFR_HUMAN (1-1210): 0: 1246: 100.00		SH3R1_HUMAN (271-339): 2.37e-11: 66.8: 20.83
+	Hs
		363102 EGFR_HUMAN (1-1210): 0: 1246: 100.00		GRB2_HUMAN (290-346): 9.97e-12: 65.5: 41.38
+	Hs
		363335 EGFR_HUMAN (1-1210): 0: 1246: 100.00		ITSN1_HUMAN (185-345): 1.53e-10: 64.6: 12.65
+	Hs
		320205 EGFR_HUMAN (1-1210): 0: 1246: 100.00		SRBS2_HUMAN (291-344): 2.02e-10: 64.3: 48.15
+	Hs
		363387 EGFR_HUMAN (1-1210): 0: 1246: 100.00		SH319_HUMAN (291-342): 6.84e-09: 59.3: 48.08
+	Hs
		987656 ERBB4_HUMAN (1-1208): 0: 1155: 49.12		GRB2_HUMAN (290-346): 9.97e-12: 65.5: 41.38
+	Hs
		410757 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		GRB2_HUMAN (290-346): 9.97e-12: 65.5: 41.38
+	Hs
		641552 ERBB3_HUMAN (1-1205): 0: 1102: 41.39		GRB2_HUMAN (290-346): 9.97e-12: 65.5: 41.38
+	Hs
		464045 RET_HUMAN (412-1058): 7.91e-132: 433: 23.02		SH3G2_HUMAN (1-347): 1.33e-86: 266: 65.91
+	Hs
		710833 EPHB2_HUMAN (642-1067): 2.14e-123: 408: 28.22		SRC8_HUMAN (7-343): 2.87e-51: 180: 14.49
+	Hs
		463937 RET_HUMAN (412-1058): 7.91e-132: 433: 23.02		GRB2_HUMAN (290-346): 9.97e-12: 65.5: 41.38
+	Hs
		932029 EPHB1_HUMAN (621-1069): 1.18e-126: 415: 27.47		GRB2_HUMAN (290-346): 9.97e-12: 65.5: 41.38
+	Mm
		932044 EPHB2_MOUSE (640-1067): 2.77e-124: 409: 28.09		GRB2_MOUSE (292-346): 1.09e-11: 65.5: 42.86
+	Hs
		710805 EPHB2_HUMAN (642-1067): 2.14e-123: 408: 28.22		GRB2_HUMAN (290-346): 9.97e-12: 65.5: 41.38