HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: CD2AP (Q9Y5K6)
CD2-associated protein (Adapter protein CMS) (Cas ligand with multiple SH3 domains)
Gene: CD2AP

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	12672817
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_1, PK_Tyr_Ser-Thr~SH3_9
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0043491 - phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0045296 - cadherin binding and 1 others more... GO:0051015 - actin filament binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 639
+	Hs
		363690 EGFR_HUMAN (1-1210): 0: 1246: 100.00		SH3K1_HUMAN (1-638): 4.71e-90: 295: 31.85
+	Hs
		221995 EGFR_HUMAN (1-1210): 0: 1246: 100.00		NCK2_HUMAN (2-361): 1.15e-52: 187: 15.86
+	Hs
		363335 EGFR_HUMAN (1-1210): 0: 1246: 100.00		ITSN1_HUMAN (2-336): 1.35e-45: 176: 19.76
+	Mm
		1030069 EGFR_MOUSE (1-1210): 0: 1267: 90.35		GRB2_MOUSE (2-168): 7.7e-42: 152: 18.06
+	Hs
		363943 EGFR_HUMAN (1-1210): 0: 1246: 100.00		ITSN2_HUMAN (2-336): 7.69e-44: 171: 18.29
+	Mm
		1030081 EGFR_MOUSE (1-1210): 0: 1267: 90.35		ARHG7_MOUSE (70-619): 1.16e-33: 139: 13.54
+	Hs
		292796 EGFR_HUMAN (1-1210): 0: 1246: 100.00		GRAP2_HUMAN (2-330): 4.32e-42: 157: 13.37
+	Rn
		988078 Q9QX70_RAT (1-1210): 0: 1250: 90.34		GRB2_RAT (2-168): 2.29e-41: 151: 18.06
+	Hs
		363102 EGFR_HUMAN (1-1210): 0: 1246: 100.00		GRB2_HUMAN (2-168): 2.29e-41: 151: 18.06
+	Hs
		363387 EGFR_HUMAN (1-1210): 0: 1246: 100.00		SH319_HUMAN (4-326): 5.26e-32: 134: 21.65
+	Hs
		362713 EGFR_HUMAN (1-1210): 0: 1246: 100.00		NCK1_HUMAN (113-396): 2.7e-26: 113: 14.38
+	Hs
		222085 ERBB4_HUMAN (1-1208): 0: 1155: 49.12		NCK2_HUMAN (2-361): 1.15e-52: 187: 15.86
+	Hs
		320205 EGFR_HUMAN (1-1210): 0: 1246: 100.00		SRBS2_HUMAN (6-215): 1.47e-19: 95.4: 18.40
+	Hs
		363274 EGFR_HUMAN (1-1210): 0: 1246: 100.00		ARHG7_HUMAN (159-362): 6.21e-12: 70.7: 20.77
+	Hs
		292835 ERBB4_HUMAN (1-1208): 0: 1155: 49.12		GRAP2_HUMAN (2-330): 4.32e-42: 157: 13.37
+	Hs
		221997 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		NCK2_HUMAN (2-361): 1.15e-52: 187: 15.86
+	Hs
		987656 ERBB4_HUMAN (1-1208): 0: 1155: 49.12		GRB2_HUMAN (2-168): 2.29e-41: 151: 18.06
+	Hs
		292799 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		GRAP2_HUMAN (2-330): 4.32e-42: 157: 13.37
+	Hs
		594007 ERBB4_HUMAN (1-1208): 0: 1155: 49.12		NCK1_HUMAN (113-396): 2.7e-26: 113: 14.38
+	Hs
		410590 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		NCK1_HUMAN (113-396): 2.7e-26: 113: 14.38