HitPredict

Interactor 1: EGFR (Q01279)
Epidermal growth factor receptor (EC 2.7.10.1)
Gene: EGFR

Interactor 2: ARHG7 (Q9ES28)
Rho guanine nucleotide exchange factor 7 (Beta-Pix) (PAK-interacting exchange factor beta) (p85SPR)
Gene: Arhgef7

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	16892055
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	CH~PK_Tyr_Ser-Thr, PH~PK_Tyr_Ser-Thr
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Mm			1 862
+	Hs
		363274 EGFR_HUMAN (1-1210): 0: 1228: 90.35		ARHG7_HUMAN (1-781): 0: 600: 90.77
+	Mm
		699350 EGFR_MOUSE (1-1210): 0: 1295: 100.00		VAV_MOUSE (1-618): 4.11e-107: 351: 18.37
+	Hs
		363013 EGFR_HUMAN (1-1210): 0: 1228: 90.35		VAV2_HUMAN (1-742): 3.04e-123: 395: 17.83
+	Hs
		364011 EGFR_HUMAN (1-1210): 0: 1228: 90.35		VAV3_HUMAN (1-665): 2.99e-112: 365: 17.58
+	Hs
		362701 EGFR_HUMAN (1-1210): 0: 1228: 90.35		VAV_HUMAN (1-666): 1.69e-105: 347: 17.37
+	Hs
		913652 ERBB4_HUMAN (7-1198): 0: 1155: 50.66		VAV2_HUMAN (1-742): 3.04e-123: 395: 17.83
+	Hs
		363674 EGFR_HUMAN (1-1210): 0: 1228: 90.35		ARHG2_HUMAN (96-860): 1.29e-93: 318: 13.04
+	Hs
		363696 EGFR_HUMAN (1-1210): 0: 1228: 90.35		Q96D37_HUMAN (53-666): 1.22e-88: 300: 15.45
+	Hs
		1145793 ERBB4_HUMAN (7-1198): 0: 1155: 50.66		VAV3_HUMAN (1-665): 2.99e-112: 365: 17.58
+	Hs
		363335 EGFR_HUMAN (1-1210): 0: 1228: 90.35		ITSN1_HUMAN (107-558): 2.38e-78: 280: 18.71
+	Hs
		363943 EGFR_HUMAN (1-1210): 0: 1228: 90.35		ITSN2_HUMAN (153-558): 3.79e-78: 279: 19.27
+	Hs
		410727 ERBB2_HUMAN (7-1203): 0: 1110: 48.34		VAV2_HUMAN (1-742): 3.04e-123: 395: 17.83
+	Hs
		584544 ERBB4_HUMAN (7-1198): 0: 1155: 50.66		VAV_HUMAN (1-666): 1.69e-105: 347: 17.37
+	Hs
		411109 ERBB2_HUMAN (7-1203): 0: 1110: 48.34		VAV3_HUMAN (1-665): 2.99e-112: 365: 17.58
+	Hs
		410582 ERBB2_HUMAN (7-1203): 0: 1110: 48.34		VAV_HUMAN (1-666): 1.69e-105: 347: 17.37
+	Hs
		410980 ERBB2_HUMAN (7-1203): 0: 1110: 48.34		ARHG2_HUMAN (96-860): 1.29e-93: 318: 13.04
+	Hs
		584470 ERBB3_HUMAN (1-1164): 0: 1065: 42.15		VAV_HUMAN (1-666): 1.69e-105: 347: 17.37
+	Hs
		410995 ERBB2_HUMAN (7-1203): 0: 1110: 48.34		Q96D37_HUMAN (53-666): 1.22e-88: 300: 15.45
+	Hs
		410558 ERBB2_HUMAN (7-1203): 0: 1110: 48.34		BCR_HUMAN (90-862): 1.19e-84: 297: 13.23
+	Hs
		238818 ERBB4_HUMAN (7-1198): 0: 1155: 50.66		KALRN_HUMAN (105-628): 4.53e-66: 243: 13.55