Protein: HPT
Haptoglobin (Zonulin) [Cleaved into: Haptoglobin alpha chain; Haptoglobin beta chain]

Gene: HPT, HP
Organism: Homo sapiens
Interactions: 111
UniProt ID: P00738

Gene Ontology (top 5):
GO:0002376 - immune system process
GO:0004252 - serine-type endopeptidase activity
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0006952 - defense response

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

366167

HBB
Hemoglobin subunit beta

2

2

Small-scale

0.754

High

132956

MATN2
Matrilin-2

1

12

High-throughput

0.691

High

210634

KLK10
Kallikrein-10

1

15

High-throughput

0.691

High

366132

HPTR
Haptoglobin-related protein

1

13

High-throughput

0.691

High

366179

FBLN7
Fibulin-7

1

15

High-throughput

0.691

High

366203

EGFL8
Epidermal growth factor-like protein 8

1

17

High-throughput

0.691

High

366166

GRB2
Growth factor receptor-bound protein 2

1

3

High-throughput

0.656

High

366136

APOA1
Apolipoprotein A-I

3

1

Small-scale

0.651

High

366133

A1AT
Alpha-1-antitrypsin

1

20

High-throughput

0.618

High

366134

AACT
Alpha-1-antichymotrypsin

1

20

High-throughput

0.618

High

366138

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

1

10

High-throughput

0.618

High

366139

FIBG
Fibrinogen gamma chain

1

10

High-throughput

0.618

High

366168

HBA
Hemoglobin subunit alpha

1

2

High-throughput

0.618

High

366221

DD19B
ATP-dependent RNA helicase DDX19B

2

1

High-throughput

0.611

High

366137

APOE
Apolipoprotein E

1

1

Small-scale

0.589

High

366176

MK06
Mitogen-activated protein kinase 6

2

2

High-throughput

0.574

High

366200

SNX27
Sorting nexin-27

2

2

High-throughput

0.574

High

366141

ALBU
Albumin

1

6

High-throughput

0.536

High

366157

CCR1
C-C chemokine receptor type 1

1

2

High-throughput

0.536

High

366178

FNDC1
Fibronectin type III domain-containing protein 1

1

2

High-throughput

0.536

High

366189

FNDC5
Fibronectin type III domain-containing protein 5

1

7

High-throughput

0.536

High

366213

NGB
Neuroglobin

1

0

High-throughput

0.517

High

351624

SG1D1
Secretoglobin family 1D member 1

1

0

High-throughput

0.513

High

366171

EXOS9
Exosome complex component RRP45

1

0

High-throughput

0.513

High

366191

ITLN2
Intelectin-2

1

0

High-throughput

0.513

High

366214

NOX4
NADPH oxidase 4

1

0

High-throughput

0.513

High

366146

HS90A
Heat shock protein HSP 90-alpha

1

3

Small-scale

0.501

High

366194

H2B1H
Histone H2B type 1-H

1

0

High-throughput

0.493

High

133832

FOXN3
Forkhead box protein N3

1

2

High-throughput

0.489

High

194431

P2RX6
P2X purinoceptor 6

1

3

High-throughput

0.489

High

318183

DDHD2
Triacylglycerol hydrolase DDHD2

1

1

High-throughput

0.489

High

355387

NSD2
Histone-lysine N-methyltransferase NSD2

1

3

High-throughput

0.489

High

366160

GSK3B
Glycogen synthase kinase-3 beta

1

2

High-throughput

0.489

High

366170

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

2

High-throughput

0.489

High

366180

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

3

High-throughput

0.489

High

366183

SFXN4
Sideroflexin-4

1

1

High-throughput

0.489

High

366192

AKAP1
A-kinase anchor protein 1, mitochondrial

1

1

High-throughput

0.489

High

366195

PMEPA
Protein TMEPAI

1

1

High-throughput

0.489

High

366196

SIA7F
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

1

6

High-throughput

0.489

High

366197

SARAF
Store-operated calcium entry-associated regulatory factor

1

1

High-throughput

0.489

High

366201

SORT
Sortilin

1

1

High-throughput

0.489

High

366202

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

3

High-throughput

0.489

High

366219

PHF11
PHD finger protein 11

1

2

High-throughput

0.489

High

366220

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

1

3

High-throughput

0.489

High

366223

SSUH2
Protein SSUH2 homolog

1

2

High-throughput

0.489

High

133620

WASL
Actin nucleation-promoting factor WASL

1

2

High-throughput

0.481

High

366225

LAMC3
Laminin subunit gamma-3

1

6

High-throughput

0.481

High

361508

CERU
Ceruloplasmin

1

5

High-throughput

0.479

High

366135

K1C14
Keratin, type I cytoskeletal 14

1

2

High-throughput

0.479

High

366142

VTDB
Vitamin D-binding protein

1

6

High-throughput

0.479

High

366143

TRFE
Serotransferrin

1

1

High-throughput

0.479

High

366144

HEMO
Hemopexin

1

1

High-throughput

0.479

High

366147

K1C16
Keratin, type I cytoskeletal 16

1

2

High-throughput

0.479

High

366151

KAP2
cAMP-dependent protein kinase type II-alpha regulatory subunit

1

1

High-throughput

0.479

High

366153

KAPCB
cAMP-dependent protein kinase catalytic subunit beta

1

2

High-throughput

0.479

High

366156

KAP3
cAMP-dependent protein kinase type II-beta regulatory subunit

1

1

High-throughput

0.479

High

366184

RBBP6
E3 ubiquitin-protein ligase RBBP6

1

1

High-throughput

0.464

High

366152

TGM2
Protein-glutamine gamma-glutamyltransferase 2

1

0

High-throughput

0.460

High

366165

RL11
Large ribosomal subunit protein uL5

1

0

High-throughput

0.460

High

366174

MVP
Major vault protein

1

0

High-throughput

0.460

High

366140

A1AG1
Alpha-1-acid glycoprotein 1

1

0

High-throughput

0.458

High

366145

STAT
Statherin

1

0

High-throughput

0.458

High

366150

CLUS
Clusterin

1

0

High-throughput

0.458

High

366155

LCN1
Lipocalin-1

1

0

High-throughput

0.458

High

366175

PROL4
Proline-rich protein 4

1

0

High-throughput

0.458

High

229252

ANGL7
Angiopoietin-related protein 7

1

10

High-throughput

0.445

High

366149

TAU
Microtubule-associated protein tau

1

5

Small-scale

0.445

High

366172

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

1

Small-scale

0.445

High

366224

PRG3
Proteoglycan 3

1

5

High-throughput

0.445

High

332125

GA45G
Growth arrest and DNA damage-inducible protein GADD45 gamma

1

1

High-throughput

0.439

High

366158

ATP7B
Copper-transporting ATPase 2

1

1

Small-scale

0.439

High

366169

SMAD3
Mothers against decapentaplegic homolog 3

1

3

High-throughput

0.439

High

366205

VKOR1
Vitamin K epoxide reductase complex subunit 1

1

4

Small-scale

0.439

High

366208

P63
Tumor protein 63

1

2

High-throughput

0.439

High

366159

RECQ1
ATP-dependent DNA helicase Q1

1

2

High-throughput

0.437

High

366163

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

4

High-throughput

0.437

High

366173

FOXO1
Forkhead box protein O1

1

3

High-throughput

0.437

High

366185

UBP48
Ubiquitin carboxyl-terminal hydrolase 48

1

7

Small-scale

0.437

High

366190

FBX22
F-box only protein 22

1

3

High-throughput

0.437

High

366193

ESR2
Estrogen receptor beta

1

5

High-throughput

0.437

High

366206

FACD2
Fanconi anemia group D2 protein

1

6

High-throughput

0.437

High

366217

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

3

High-throughput

0.437

High

366218

ZRAN1
Ubiquitin thioesterase ZRANB1

1

7

High-throughput

0.437

High

366148

LEG1
Galectin-1

1

0

High-throughput

0.426

High

366154

CRHBP
Corticotropin-releasing factor-binding protein

1

0

High-throughput

0.426

High

366162

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

0

High-throughput

0.426

High

366164

RL10A
Large ribosomal subunit protein uL1

1

0

High-throughput

0.426

High

261037

NSMA
Sphingomyelin phosphodiesterase 2

1

1

High-throughput

0.407

High

346582

TTC4
Tetratricopeptide repeat protein 4

1

1

High-throughput

0.407

High

366182

A16L1
Autophagy-related protein 16-1

1

4

High-throughput

0.407

High

366186

SLX4
Structure-specific endonuclease subunit SLX4

1

1

High-throughput

0.407

High

366181

ICE2
Little elongation complex subunit 2

3

0

High-throughput

0.347

High

366188

GDPD1
Lysophospholipase D GDPD1

3

0

High-throughput

0.347

High

366209

DDX31
ATP-dependent DNA helicase DDX31

2

0

High-throughput

0.328

High

231356

PDE6D
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta

1

0

High-throughput

0.279

Low

254709

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.279

Low

366161

STX17
Syntaxin-17

1

0

High-throughput

0.279

Low

366177

T176B
Transmembrane protein 176B

1

0

High-throughput

0.279

Low

366187

DTWD1
tRNA-uridine aminocarboxypropyltransferase 1

1

0

High-throughput

0.279

Low

366198

TOPK
Lymphokine-activated killer T-cell-originated protein kinase

1

0

High-throughput

0.279

Low

366199

SMIM8
Small integral membrane protein 8

1

0

High-throughput

0.279

Low

366204

USB1
U6 snRNA phosphodiesterase 1

1

0

High-throughput

0.279

Low

366210

PPCS
Phosphopantothenate--cysteine ligase

1

0

High-throughput

0.279

Low

366211

COE2
Transcription factor COE2

1

0

High-throughput

0.279

Low

366212

CP343
Cytochrome P450 3A43

1

0

High-throughput

0.279

Low

366215

MBNL1
Muscleblind-like protein 1

1

0

High-throughput

0.279

Low

366216

PLS4
Phospholipid scramblase 4

1

0

High-throughput

0.279

Low

366222

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

1

0

Small-scale

0.278

Low

366207

MIS12
Protein MIS12 homolog

1

0

High-throughput

0.269

Low

261357

TBL1X
F-box-like/WD repeat-containing protein TBL1X

1

0

High-throughput

0.251

Low

219582

B2L11
Bcl-2-like protein 11

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025