HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: LS14A (Q8ND56)
Protein LSM14 homolog A (Protein FAM61A) (Protein SCD6 homolog) (Putative alpha-synuclein-binding protein) (AlphaSNBP) (RNA-associated protein 55A) (hRAP55) (hRAP55A)
Gene: LSM14A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	31527615, unassigned1953
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 595 Hs			1 463
+	Hs
		370354 ESR1_HUMAN (1-595): 0: 599: 100.00		LS14B_HUMAN (2-401): 1.81e-74: 240: 45.70
+	Hs
		1242093 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		LS14A_HUMAN (1-463): 2.65e-117: 353: 100.00
+	Hs
		225328 ESR1_HUMAN (1-595): 0: 599: 100.00		MED14_HUMAN (54-294): 6.38e-25: 110: 15.39
+	Mm
		101423 ESR1_MOUSE (1-595): 0: 570: 88.98		F8VPR5_MOUSE (74-395): 2.42e-21: 99.6: 12.42
+	Hs
		370607 ESR1_HUMAN (1-595): 0: 599: 100.00		CHD7_HUMAN (82-373): 1.03e-10: 66.5: 12.00
+	Hs
		370040 ESR1_HUMAN (1-595): 0: 599: 100.00		KMT2C_HUMAN (45-386): 8.05e-10: 63.8: 12.25
+	Hs
		1269521 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		LS14B_HUMAN (2-401): 1.81e-74: 240: 45.70
+	Hs
		225402 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		MED14_HUMAN (54-294): 6.38e-25: 110: 15.39
+	Hs
		1270066 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PCLO_HUMAN (51-386): 1.86e-17: 87.7: 11.47
+	Mm
		101427 RXRG_MOUSE (49-549): 5.25e-129: 388: 23.51		F8VPR5_MOUSE (74-395): 2.42e-21: 99.6: 12.42
+	Hs
		1269810 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		CHD7_HUMAN (82-373): 1.03e-10: 66.5: 12.00
+	Hs
		302306 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		SC31A_HUMAN (69-294): 1.26e-10: 66.1: 13.16
+	Hs
		1243831 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		KMT2C_HUMAN (45-386): 8.05e-10: 63.8: 12.25
+	Hs
		225354 HNF4A_HUMAN (146-592): 2.13e-118: 361: 20.58		MED14_HUMAN (54-294): 6.38e-25: 110: 15.39
+	Hs
		867111 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		SC24C_HUMAN (106-353): 5.82e-09: 60.7: 10.08
+	Mm
		57035 ERR2_MOUSE (92-547): 6.98e-113: 345: 34.42		MED14_MOUSE (54-294): 8.12e-27: 116: 14.23
+	Hs
		225330 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		MED14_HUMAN (54-294): 6.38e-25: 110: 15.39
+	Hs
		782677 HNF4A_HUMAN (146-592): 2.13e-118: 361: 20.58		CHD7_HUMAN (82-373): 1.03e-10: 66.5: 12.00
+	Hs
		782595 HNF4A_HUMAN (146-592): 2.13e-118: 361: 20.58		KMT2C_HUMAN (45-386): 8.05e-10: 63.8: 12.25
+	Hs
		377760 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		CHD7_HUMAN (82-373): 1.03e-10: 66.5: 12.00