Protein: CYTC
Cystatin-C (Cystatin-3) (Gamma-trace) (Neuroendocrine basic polypeptide) (Post-gamma-globulin)

Gene: CYTC, CST3
Organism: Homo sapiens
Interactions: 31
UniProt ID: P01034

Gene Ontology (top 5):
GO:0001540 - amyloid-beta binding
GO:0002020 - protease binding
GO:0004866 - endopeptidase inhibitor activity
GO:0004869 - cysteine-type endopeptidase inhibitor activity
GO:0005576 - extracellular region

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

370042

LGMN
Legumain

2

3

Small-scale

0.840

High

370024

CYTC
Cystatin-C

2

2

Small-scale

0.827

High

370029

CATB
Cathepsin B

2

17

Small-scale

0.799

High

261578

CATL2
Cathepsin L2

1

13

High-throughput

0.691

High

370028

CATL1
Procathepsin L

1

13

High-throughput

0.691

High

370030

CATH
Pro-cathepsin H [Cleaved into: Cathepsin H mini chain; Cathepsin H

1

13

High-throughput

0.691

High

370033

CATO
Cathepsin O

1

15

High-throughput

0.691

High

370035

CATC
Dipeptidyl peptidase 1

1

17

High-throughput

0.691

High

370046

DDX31
ATP-dependent DNA helicase DDX31

2

3

High-throughput

0.628

High

370026

CYTB
Cystatin-B

1

0

Small-scale

0.614

High

370043

ZNG1A
Zinc-regulated GTPase metalloprotein activator 1A

1

1

High-throughput

0.536

High

370047

BIRC6
Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6

1

1

High-throughput

0.536

High

370049

LCAP
Leucyl-cystinyl aminopeptidase

1

1

High-throughput

0.536

High

370027

A4
Amyloid-beta precursor protein

1

6

High-throughput

0.515

High

370025

ALBU
Albumin

1

0

High-throughput

0.513

High

370034

MAOX
NADP-dependent malic enzyme

1

0

High-throughput

0.513

High

370037

HPCA
Neuron-specific calcium-binding protein hippocalcin

1

0

High-throughput

0.513

High

370045

TX101
Testis-expressed protein 101

1

0

High-throughput

0.513

High

370039

ZER1
Protein zer-1 homolog

1

1

High-throughput

0.489

High

370036

ATX1
Ataxin-1

1

0

High-throughput

0.486

High

370031

CO4A
Complement C4-A

1

0

Small-scale

0.480

High

370032

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.479

High

370050

RN115
E3 ubiquitin-protein ligase RNF115

1

0

Small-scale

0.460

High

217683

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

370038

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

370048

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

261043

NSMA
Sphingomyelin phosphodiesterase 2

1

1

High-throughput

0.445

High

370041

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

1

Small-scale

0.445

High

370044

RSRP1
Arginine/serine-rich protein 1

1

1

High-throughput

0.407

High

370040

SAPC2
Suppressor APC domain-containing protein 2

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025