HitPredict

Interactor 1: MMP1 (P03956)
Interstitial collagenase (EC 3.4.24.7) (Fibroblast collagenase) (Matrix metalloproteinase-1) (MMP-1) [Cleaved into: 22 kDa interstitial collagenase; 27 kDa interstitial collagenase]
Gene: MMP1

Interactor 2: CXCL6 (P80162)
C-X-C motif chemokine 6 (Chemokine alpha 3) (CKA-3) (Granulocyte chemotactic protein 2) (GCP-2) (Small-inducible cytokine B6) [Cleaved into: Small-inducible cytokine B6, N-processed variant 1; Small-inducible cytokine B6, N-processed variant 2; Small-inducible cytokine B6, N-processed variant 3]
Gene: CXCL6

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	18660381
Identification Methods	protease assay
Interaction Type	protein cleavage

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005576 - extracellular region GO:0005615 - extracellular space
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 469 Hs			1 114
+	Hs
		372733 MMP1_HUMAN (1-469): 0: 663: 100.00		CXCL5_HUMAN (1-114): 6.11e-39: 127: 79.83
+	Hs
		364034 MMP1_HUMAN (1-469): 0: 663: 100.00		CXCL7_HUMAN (36-114): 3.87e-28: 100: 40.51
+	Hs
		372731 MMP1_HUMAN (1-469): 0: 663: 100.00		CXCL2_HUMAN (38-112): 2.26e-27: 98.6: 40.00
+	Hs
		372724 MMP1_HUMAN (1-469): 0: 663: 100.00		IL8_HUMAN (34-113): 1.04e-25: 94: 29.63
+	Hs
		764724 MMP12_HUMAN (7-466): 0: 619: 48.93		CXCL5_HUMAN (1-114): 6.11e-39: 127: 79.83
+	Hs
		612139 MMP8_HUMAN (16-467): 0: 608: 58.15		CXCL5_HUMAN (1-114): 6.11e-39: 127: 79.83
+	Hs
		764727 MMP12_HUMAN (7-466): 0: 619: 48.93		CXCL6_HUMAN (1-114): 2.56e-34: 116: 100.00
+	Hs
		486190 MMP13_HUMAN (4-466): 0: 626: 47.65		IL8_HUMAN (34-113): 1.04e-25: 94: 29.63
+	Hs
		364043 MMP12_HUMAN (7-466): 0: 619: 48.93		CXCL7_HUMAN (36-114): 3.87e-28: 100: 40.51
+	Hs
		587770 MMP12_HUMAN (7-466): 0: 619: 48.93		CXCL2_HUMAN (38-112): 2.26e-27: 98.6: 40.00
+	Hs
		587787 MMP12_HUMAN (7-466): 0: 619: 48.93		CXCL3_HUMAN (43-112): 1.33e-26: 96.7: 45.71
+	Hs
		448989 MMP12_HUMAN (7-466): 0: 619: 48.93		GROA_HUMAN (43-112): 2.47e-26: 95.9: 45.71
+	Hs
		486188 MMP12_HUMAN (7-466): 0: 619: 48.93		IL8_HUMAN (34-113): 1.04e-25: 94: 29.63
+	Hs
		486182 MMP8_HUMAN (16-467): 0: 608: 58.15		IL8_HUMAN (34-113): 1.04e-25: 94: 29.63
+	Mm
		714630 MMP12_MOUSE (6-466): 0: 566: 43.56		CXCL5_MOUSE (1-113): 1.09e-38: 127: 58.12
+	Mm
		500671 MMP12_MOUSE (6-466): 0: 566: 43.56		CXCL2_MOUSE (38-112): 1.64e-28: 101: 50.67
+	Mm
		522396 MMP12_MOUSE (6-466): 0: 566: 43.56		GROA_MOUSE (39-109): 1.59e-27: 98.6: 45.07
+	Mm
		714631 MMP12_MOUSE (6-466): 0: 566: 43.56		CXCL3_MOUSE (38-113): 5.91e-27: 97.1: 46.05
+	Hs
		364037 MMP9_HUMAN (20-206): 1.37e-71: 241: 48.13		CXCL7_HUMAN (36-114): 3.87e-28: 100: 40.51
+	Hs
		486175 MMP9_HUMAN (20-206): 1.37e-71: 241: 48.13		IL8_HUMAN (34-113): 1.04e-25: 94: 29.63