Protein: KDM5A
Lysine-specific demethylase 5A (EC 1.14.11.67) (Histone demethylase JARID1A) (Jumonji/ARID domain-containing protein 1A) (Retinoblastoma-binding protein 2) (RBBP-2) ([histone H3]-trimethyl-L-lysine(4) demethylase 5A)

Gene: KDM5A
Organism: Homo sapiens
Interactions: 66
UniProt ID: P29375

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0003677 - DNA binding
GO:0003713 - transcription coactivator activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

711844

MO4L1
Mortality factor 4-like protein 1

7

5

Small-scale

0.962

High

711818

HDAC1
Histone deacetylase 1

5

14

High-throughput

0.930

High

274285

SIN3B
Paired amphipathic helix protein Sin3b

4

2

Small-scale

0.903

High

711819

MO4L2
Mortality factor 4-like protein 2

4

5

Small-scale

0.881

High

711838

PHF12
PHD finger protein 12

3

9

High-throughput

0.861

High

711846

ZMYD8
MYND-type zinc finger-containing chromatin reader ZMYND8

3

7

Small-scale

0.847

High

711837

HDAC2
Histone deacetylase 2

2

14

Small-scale

0.789

High

711809

H31
Histone H3.1

2

20

Small-scale

0.768

High

711833

GATD1
GATA zinc finger domain-containing protein 1

6

1

High-throughput

0.736

High

442607

RB
Retinoblastoma-associated protein

5

4

Small-scale

0.720

High

711824

RBBP7
Histone-binding protein RBBP7

4

14

High-throughput

0.699

High

74439

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

1

High-throughput

0.691

High

395550

ESR1
Estrogen receptor

3

20

Small-scale

0.660

High

711829

H32
Histone H3.2

1

20

Small-scale

0.647

High

711816

RBBP4
Histone-binding protein RBBP4

3

14

High-throughput

0.643

High

161416

KMT2D
Histone-lysine N-methyltransferase 2D

1

20

Small-scale

0.618

High

711802

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

1

High-throughput

0.618

High

711810

H33
Histone H3.3

1

20

High-throughput

0.618

High

711812

KMT2A
Histone-lysine N-methyltransferase 2A

1

20

Small-scale

0.618

High

711828

LARP7
La-related protein 7

1

1

High-throughput

0.618

High

711841

BRD8
Bromodomain-containing protein 8

1

11

High-throughput

0.618

High

711830

EMSY
BRCA2-interacting transcriptional repressor EMSY

2

9

High-throughput

0.611

High

711815

SUH
Recombining binding protein suppressor of hairless

1

2

Small-scale

0.586

High

681754

RBTN2
Rhombotin-2

1

7

Small-scale

0.573

High

711811

FOXK2
Forkhead box protein K2

1

7

High-throughput

0.536

High

711825

H31T
Histone H3.1t

1

20

High-throughput

0.527

High

711839

MYCBP
c-Myc-binding protein

1

0

High-throughput

0.513

High

711848

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

1

0

High-throughput

0.513

High

403846

GCR
Glucocorticoid receptor

1

20

Small-scale

0.501

High

520518

RARA
Retinoic acid receptor alpha

1

16

Small-scale

0.501

High

543467

VDR
Vitamin D3 receptor

1

15

Small-scale

0.501

High

704916

RBL1
Retinoblastoma-like protein 1

1

4

Small-scale

0.501

High

711799

TCPZ
T-complex protein 1 subunit zeta

1

11

High-throughput

0.494

High

711808

TBA1B
Tubulin alpha-1B chain

1

4

High-throughput

0.489

High

628710

TBP
TATA-box-binding protein

1

0

Small-scale

0.480

High

285098

EED
Polycomb protein EED

1

14

Small-scale

0.479

High

400335

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.479

High

565782

EF2
Elongation factor 2

1

1

High-throughput

0.479

High

711798

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

2

High-throughput

0.479

High

711800

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

10

High-throughput

0.479

High

711801

MECP2
Methyl-CpG-binding protein 2

1

5

High-throughput

0.479

High

711803

ZN131
Zinc finger protein 131

1

1

High-throughput

0.479

High

711804

KLF3
Krueppel-like factor 3

1

7

High-throughput

0.479

High

711806

WDR5
WD repeat-containing protein 5

1

8

Small-scale

0.479

High

711807

H4
Histone H4

1

6

High-throughput

0.479

High

711813

1433F
14-3-3 protein eta

1

6

High-throughput

0.479

High

711814

MAD1
Max dimerization protein 1

1

4

Small-scale

0.479

High

711817

AHNK
Neuroblast differentiation-associated protein AHNAK

1

4

High-throughput

0.479

High

711820

SUZ12
Polycomb protein SUZ12

1

6

Small-scale

0.479

High

711821

EEA1
Early endosome antigen 1

1

2

High-throughput

0.479

High

711822

ELF2
ETS-related transcription factor Elf-2

1

10

High-throughput

0.479

High

711823

EZH2
Histone-lysine N-methyltransferase EZH2

1

18

Small-scale

0.479

High

711826

PDS5A
Sister chromatid cohesion protein PDS5 homolog A

1

1

High-throughput

0.479

High

711831

PALB2
Partner and localizer of BRCA2

1

1

High-throughput

0.479

High

711832

NUP43
Nucleoporin Nup43

1

18

High-throughput

0.479

High

711836

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

711840

NAA15
N-alpha-acetyltransferase 15, NatA auxiliary subunit

1

2

High-throughput

0.479

High

711843

MRGBP
MRG/MORF4L-binding protein

1

1

High-throughput

0.479

High

711845

XPO7
Exportin-7

1

6

High-throughput

0.479

High

711847

KLF12
Krueppel-like factor 12

1

7

High-throughput

0.479

High

711842

LN28A
Protein lin-28 homolog A

1

2

High-throughput

0.445

High

711827

BLTP1
Bridge-like lipid transfer protein family member 1

1

0

High-throughput

0.426

High

711835

TM9S4
Transmembrane 9 superfamily member 4

1

0

High-throughput

0.279

Low

345409

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.249

Low

711834

POF1B
Protein POF1B

1

0

High-throughput

0.249

Low

711805

DSCR9
Down syndrome critical region protein 9

1

0

High-throughput

0.238

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025