HitPredict

Interactor 1: H2B (P02283)
Histone H2B
Gene: H2B, His2B;

Interactor 2: H4 (P84040)
Histone H4
Gene: His4

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	27956707
Identification Methods	protein complementation assay
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	CENP-T_C~Histone
Common GO terms	GO:0000786 - nucleosome GO:0003677 - DNA binding GO:0030527 - structural constituent of chromatin GO:0046982 - protein heterodimerization activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 123 Dm			1 103
+	Hs
		980215 H2B1M_HUMAN (3-123): 2.31e-49: 155: 80.49		H4_HUMAN (1-103): 1.72e-48: 151: 99.03
+	Hs
		659883 H2B1O_HUMAN (3-123): 3.31e-49: 154: 82.11		H4_HUMAN (1-103): 1.72e-48: 151: 99.03
+	Hs
		979785 H2B2F_HUMAN (3-123): 3.46e-49: 154: 81.30		H4_HUMAN (1-103): 1.72e-48: 151: 99.03
+	Hs
		980094 H2B1H_HUMAN (3-123): 5.3e-49: 154: 81.30		H4_HUMAN (1-103): 1.72e-48: 151: 99.03
+	Hs
		449698 H2B1J_HUMAN (3-123): 1.27e-48: 153: 81.30		H4_HUMAN (1-103): 1.72e-48: 151: 99.03
+	Hs
		754783 H2B1B_HUMAN (3-123): 1.14e-48: 153: 82.11		H4_HUMAN (1-103): 1.72e-48: 151: 99.03
+	Hs
		943338 H2BFS_HUMAN (3-123): 1.73e-48: 153: 78.86		H4_HUMAN (1-103): 1.72e-48: 151: 99.03
+	Hs
		979449 H2B1C_HUMAN (3-123): 1.52e-48: 153: 81.30		H4_HUMAN (1-103): 1.72e-48: 151: 99.03
+	Hs
		979743 H2B2E_HUMAN (3-123): 9.57e-49: 153: 82.11		H4_HUMAN (1-103): 1.72e-48: 151: 99.03
+	Hs
		256819 H2B1K_HUMAN (3-123): 2.13e-48: 152: 80.49		H4_HUMAN (1-103): 1.72e-48: 151: 99.03
+	Hs
		946738 H2B1D_HUMAN (3-123): 2.77e-48: 152: 81.30		H4_HUMAN (1-103): 1.72e-48: 151: 99.03
+	Hs
		980213 H2B1N_HUMAN (3-123): 2.93e-48: 152: 81.30		H4_HUMAN (1-103): 1.72e-48: 151: 99.03
+	Xl
		380868 H2B11_XENLA (3-123): 1.92e-47: 150: 80.49		H4_XENLA (1-103): 1.72e-48: 151: 99.03
+	Hs
		980216 H2B1L_HUMAN (4-123): 2.64e-47: 149: 81.15		H4_HUMAN (1-103): 1.72e-48: 151: 99.03
+	Hs
		979974 H2B3B_HUMAN (3-123): 1.15e-46: 148: 81.30		H4_HUMAN (1-103): 1.72e-48: 151: 99.03
+	Hs
		980103 H2B1A_HUMAN (3-123): 2.13e-43: 139: 78.57		H4_HUMAN (1-103): 1.72e-48: 151: 99.03
+	Hs
		1163161 H2B2E_HUMAN (3-123): 9.57e-49: 153: 82.11		H4G_HUMAN (1-98): 1.4e-38: 126: 83.67
+	Hs
		256966 H2B1K_HUMAN (3-123): 2.13e-48: 152: 80.49		H4G_HUMAN (1-98): 1.4e-38: 126: 83.67
+	Hs
		946863 H2B1D_HUMAN (3-123): 2.77e-48: 152: 81.30		H4G_HUMAN (1-98): 1.4e-38: 126: 83.67
+	Hs
		1405082 H2B1L_HUMAN (4-123): 2.64e-47: 149: 81.15		H4G_HUMAN (1-98): 1.4e-38: 126: 83.67