Interactor 1: NTRK1 (P04629)
High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA)
Gene: NTRK1
Interactor 2: NTRK1 (P04629)
High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA)
Gene: NTRK1
Species: Homo sapiens
Source: mint
Category: Small-scale
Confidence: High
Method score | Annotation score | Interaction score |
---|---|---|
0.86 | 1.00 | 0.928 |
The method score is based on:
Property | Details |
---|---|
Experiments | 25921289, 26285778, 31801826, 10388563, 28197073, 21187090 |
Identification Methods | affinity chromatography technology, enzymatic study, x-ray crystallography, bimolecular fluorescence complementation, protein complementation assay |
Interaction Type | physical association, direct interaction, association |
The annotation score is based on:
Property | Details |
---|---|
Interacting Pfam domains | LRR_8~LRR_8, LRRCT_2~LRR_8, LRR_8~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr, TrkA_TMD~TrkA_TMD |
Common GO terms | GO:0001934 - positive regulation of protein phosphorylation GO:0004713 - protein tyrosine kinase activity GO:0004714 - transmembrane receptor protein tyrosine kinase activity GO:0005004 - GPI-linked ephrin receptor activity GO:0005030 - neurotrophin receptor activity and 62 others more... |
Homologous interactions | 18 |
Homologous interactions
Color coding for hit scores
Service provided by Combinatics, Japan
Last updated: 15 Jul 2024