HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: LIMK2 (P53671)
LIM domain kinase 2 (LIMK-2) (EC 2.7.11.1)
Gene: LIMK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.621

Property	Details
Experiments	32707033, 22939624
Identification Methods	affinity chromatography technology, pull down, luminescence based mammalian interactome mapping, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 638
+	Hs
		431684 HS90A_HUMAN (1-724): 0: 1072: 85.25		LIMK2_HUMAN (1-638): 0: 577: 100.00
+	Hs
		438022 HS90B_HUMAN (1-724): 0: 1086: 100.00		LIMK1_HUMAN (6-638): 1.03e-170: 503: 52.73
+	Hs
		431683 HS90A_HUMAN (1-724): 0: 1072: 85.25		LIMK1_HUMAN (6-638): 1.03e-170: 503: 52.73
+	Hs
		438028 HS90B_HUMAN (1-724): 0: 1086: 100.00		EPHB1_HUMAN (7-632): 4.77e-154: 471: 17.54
+	Hs
		438029 HS90B_HUMAN (1-724): 0: 1086: 100.00		EPHA4_HUMAN (7-631): 3.48e-149: 458: 18.13
+	Hs
		431691 HS90A_HUMAN (1-724): 0: 1072: 85.25		EPHB1_HUMAN (7-632): 4.77e-154: 471: 17.54
+	Hs
		431562 HS90A_HUMAN (1-724): 0: 1072: 85.25		EPHA3_HUMAN (7-629): 2.44e-151: 463: 18.27
+	Hs
		431692 HS90A_HUMAN (1-724): 0: 1072: 85.25		EPHA4_HUMAN (7-631): 3.48e-149: 458: 18.13
+	Hs
		437918 HS90B_HUMAN (1-724): 0: 1086: 100.00		EPHA2_HUMAN (9-636): 4.26e-137: 426: 18.52
+	Hs
		437892 HS90B_HUMAN (1-724): 0: 1086: 100.00		EPHA1_HUMAN (5-636): 6.05e-133: 416: 19.06
+	Hs
		431561 HS90A_HUMAN (1-724): 0: 1072: 85.25		EPHA2_HUMAN (9-636): 4.26e-137: 426: 18.52
+	Hs
		538167 ENPL_HUMAN (3-693): 0: 917: 46.44		LIMK2_HUMAN (1-638): 0: 577: 100.00
+	Hs
		431531 HS90A_HUMAN (1-724): 0: 1072: 85.25		EPHA1_HUMAN (5-636): 6.05e-133: 416: 19.06
+	Hs
		438195 HS90B_HUMAN (1-724): 0: 1086: 100.00		TESK1_HUMAN (313-637): 6.25e-96: 309: 40.85
+	Hs
		431880 HS90A_HUMAN (1-724): 0: 1072: 85.25		TESK1_HUMAN (313-637): 6.25e-96: 309: 40.85
+	Hs
		438454 HS90B_HUMAN (1-724): 0: 1086: 100.00		TESK2_HUMAN (335-610): 2.37e-60: 213: 40.86
+	Hs
		538261 ENPL_HUMAN (3-693): 0: 917: 46.44		EPHAA_HUMAN (10-632): 5.95e-118: 377: 17.71
+	Hs
		432182 HS90A_HUMAN (1-724): 0: 1072: 85.25		TESK2_HUMAN (335-610): 2.37e-60: 213: 40.86
+	Hs
		437867 HS90B_HUMAN (1-724): 0: 1086: 100.00		FER_HUMAN (330-598): 2.19e-29: 126: 31.73
+	Hs
		431507 HS90A_HUMAN (1-724): 0: 1072: 85.25		FER_HUMAN (330-598): 2.19e-29: 126: 31.73