HitPredict

Interactor 1: NTRK1 (P04629)
High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA)
Gene: NTRK1

Interactor 2: MILK1 (Q8N3F8)
MICAL-like protein 1 (Molecule interacting with Rab13) (MIRab13)
Gene: MICALL1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	LIM~LRR_8, CH~PK_Tyr_Ser-Thr
Common GO terms	GO:0005770 - late endosome GO:0031175 - neuron projection development GO:0031902 - late endosome membrane GO:0055038 - recycling endosome membrane
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 796 Hs			1 863
+	Hs
		384183 NTRK1_HUMAN (1-796): 0: 621: 100.00		ACTN1_HUMAN (3-227): 1.28e-64: 235: 29.78
+	Hs
		211458 NTRK1_HUMAN (1-796): 0: 621: 100.00		ACTN4_HUMAN (3-227): 5.94e-64: 233: 29.78
+	Hs
		508099 FGFR1_HUMAN (195-794): 0: 545: 26.34		MILK1_HUMAN (1-863): 1.02e-88: 302: 100.00
+	Hs
		384662 NTRK1_HUMAN (1-796): 0: 621: 100.00		SPTB2_HUMAN (3-246): 8.29e-57: 215: 28.69
+	Hs
		508107 FGFR1_HUMAN (195-794): 0: 545: 26.34		EHBP1_HUMAN (3-833): 2.93e-73: 263: 15.93
+	Hs
		608045 FGFR4_HUMAN (140-795): 7.96e-168: 506: 25.59		MILK1_HUMAN (1-863): 1.02e-88: 302: 100.00
+	Hs
		385216 NTRK1_HUMAN (1-796): 0: 621: 100.00		MICA1_HUMAN (377-811): 1.09e-42: 170: 18.40
+	Hs
		1081536 NTRK3_HUMAN (36-796): 1.63e-174: 525: 49.37		EHBP1_HUMAN (3-833): 2.93e-73: 263: 15.93
+	Hs
		608048 FGFR4_HUMAN (140-795): 7.96e-168: 506: 25.59		EHBP1_HUMAN (3-833): 2.93e-73: 263: 15.93
+	Mm
		1149117 PTK7_MOUSE (201-781): 5.12e-148: 462: 27.17		EHBP1_MOUSE (3-833): 5.21e-70: 254: 16.17
+	Hs
		508077 FGFR1_HUMAN (195-794): 0: 545: 26.34		MICA3_HUMAN (8-107): 1.44e-22: 106: 54.00
+	Hs
		872461 EPHA5_HUMAN (409-788): 2.48e-111: 365: 30.36		EHBP1_HUMAN (3-833): 2.93e-73: 263: 15.93
+	Hs
		435697 IGF1R_HUMAN (493-777): 6.97e-71: 255: 42.61		EHBP1_HUMAN (3-833): 2.93e-73: 263: 15.93
+	Hs
		411443 INSR_HUMAN (493-777): 3e-68: 248: 42.62		EHBP1_HUMAN (3-833): 2.93e-73: 263: 15.93
+	Hs
		211691 ALK_HUMAN (505-790): 8.72e-63: 231: 42.07		ACTN4_HUMAN (3-227): 5.94e-64: 233: 29.78
+	Rn
		88607 INSR_RAT (493-777): 7.31e-66: 241: 41.95		D3ZGN7_RAT (684-825): 6.18e-18: 91.7: 38.89