HitPredict

Interactor 1: CPNS1 (P04632)
Calpain small subunit 1 (CSS1) (Calcium-activated neutral proteinase small subunit) (CANP small subunit) (Calcium-dependent protease small subunit) (CDPS) (Calcium-dependent protease small subunit 1) (Calpain regulatory subunit)
Gene: CAPNS1

Interactor 2: HUWE1 (Q7Z6Z7)
E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1)
Gene: HUWE1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	25147182
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0016020 - membrane GO:0070062 - extracellular exosome
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 268 Hs			1 4374
+	Hs
		125078 CPNS1_HUMAN (1-268): 6.37e-71: 220: 100.00		WWP2_HUMAN (3506-4372): 0: 624: 24.57
+	Hs
		385887 CPNS1_HUMAN (1-268): 6.37e-71: 220: 100.00		WWP1_HUMAN (3507-4372): 0: 613: 22.55
+	Hs
		125773 PEF1_HUMAN (45-265): 3.98e-55: 180: 22.47		WWP2_HUMAN (3506-4372): 0: 624: 24.57
+	Hs
		125042 PDCD6_HUMAN (103-265): 2.75e-55: 178: 27.27		WWP2_HUMAN (3506-4372): 0: 624: 24.57
+	Hs
		484077 CALM3_HUMAN (56-171): 1.29e-16: 76.5: 20.16		NEDD4_HUMAN (3104-4372): 2.46e-179: 594: 21.46
+	Hs
		808300 CALL5_HUMAN (172-258): 9.88e-10: 57.6: 31.52		NEDD4_HUMAN (3104-4372): 2.46e-179: 594: 21.46
+	Hs
		648627 CALL3_HUMAN (56-167): 2.07e-15: 73.4: 20.00		HECW2_HUMAN (3131-4373): 4.71e-161: 547: 20.49