HitPredict

Interactor 1: P53 (P04637)
Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
Gene: TP53

Interactor 2: S10A4 (P26447)
Protein S100-A4 (Calvasculin) (Metastasin) (Placental calcium-binding protein) (Protein Mts1) (S100 calcium-binding protein A4)
Gene: S100A4

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.971

Property	Details
Experiments	11278647, 11527429, 20070253, 19740107, 31837246, 20591429, 23752197
Identification Methods	affinity chromatography technology, pull down, far western blotting, biochemical, fluorescence polarization spectroscopy, molecular sieving, cross-linking study
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	S_100~TAD2
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 393 Hs			1 101
+	Hs
		386104 P53_HUMAN (1-393): 0: 619: 100.00		S10A1_HUMAN (1-90): 7.9e-37: 121: 51.11
+	Hs
		387043 P53_HUMAN (1-393): 0: 619: 100.00		HORN_HUMAN (1-96): 6.3e-33: 121: 25.74
+	Hs
		386185 P53_HUMAN (1-393): 0: 619: 100.00		S10AB_HUMAN (2-97): 2.99e-36: 120: 27.84
+	Hs
		386155 P53_HUMAN (1-393): 0: 619: 100.00		S10A2_HUMAN (1-97): 1.08e-35: 118: 60.83
+	Hs
		386132 P53_HUMAN (1-393): 0: 619: 100.00		S100P_HUMAN (3-96): 6.88e-35: 116: 41.49
+	Hs
		386865 P53_HUMAN (1-393): 0: 619: 100.00		FILA2_HUMAN (3-100): 5.37e-31: 116: 29.13
+	Hs
		386192 P53_HUMAN (1-393): 0: 619: 100.00		S10A3_HUMAN (1-98): 2.48e-34: 115: 45.92
+	Hs
		386412 P53_HUMAN (1-393): 0: 619: 100.00		S10AA_HUMAN (1-100): 4.52e-32: 109: 34.00
+	Hs
		380714 P53_HUMAN (1-393): 0: 619: 100.00		S100B_HUMAN (3-91): 3.86e-31: 106: 47.19
+	Hs
		385924 P53_HUMAN (1-393): 0: 619: 100.00		S10A6_HUMAN (1-92): 1.7e-28: 100: 50.00
+	Hs
		386512 P53_HUMAN (1-393): 0: 619: 100.00		S10AC_HUMAN (3-87): 4.08e-28: 99.1: 35.29
+	Hs
		385910 P53_HUMAN (1-393): 0: 619: 100.00		S10A8_HUMAN (1-88): 8.31e-25: 91: 29.55
+	Hs
		386191 P53_HUMAN (1-393): 0: 619: 100.00		S10A5_HUMAN (1-90): 7.24e-25: 91: 53.33
+	Hs
		387288 P53_HUMAN (1-393): 0: 619: 100.00		S10AG_HUMAN (3-83): 1.43e-23: 87.9: 37.81
+	Hs
		387371 P53_HUMAN (1-393): 0: 619: 100.00		S10AD_HUMAN (3-84): 4.72e-22: 84.1: 34.15