HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: KRT82 (Q9NSB4)
Keratin, type II cuticular Hb2 (Keratin-82) (K82) (Type II hair keratin Hb2) (Type-II keratin Kb22)
Gene: KRT82

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	19380743
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 217 Hs			1 513
+	Hs
		475752 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		K2C7_HUMAN (1-497): 5.76e-160: 464: 50.10
+	Hs
		407424 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		K2C1_HUMAN (88-445): 2.84e-131: 397: 56.79
+	Hs
		437141 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		K2C8_HUMAN (42-460): 1.16e-110: 339: 51.66
+	Hs
		987536 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		KRT85_HUMAN (1-487): 4.45e-102: 317: 60.73
+	Hs
		987535 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		KRT83_HUMAN (1-470): 3.1e-100: 312: 58.60
+	Hs
		987642 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		KRT81_HUMAN (7-511): 5.98e-100: 312: 56.31
+	Hs
		227210 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		KRT86_HUMAN (7-496): 9.57e-100: 311: 57.03
+	Hs
		987749 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		K2C73_HUMAN (1-512): 1.03e-94: 299: 42.38
+	Hs
		566356 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		K2C5_HUMAN (1-434): 1.91e-76: 253: 48.35
+	Hs
		385258 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		K2C6A_HUMAN (73-434): 1.13e-73: 245: 58.79
+	Mm
		1133331 GRB2_MOUSE (1-217): 5.96e-71: 217: 99.54		Q148Q7_MOUSE (1-434): 4.16e-69: 232: 50.11
+	Mm
		1221237 GRB2_MOUSE (1-217): 5.96e-71: 217: 99.54		Q8BIS2_MOUSE (1-434): 4.2e-69: 232: 50.11
+	Hs
		987814 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		KRT35_HUMAN (9-479): 4.26e-70: 232: 24.58
+	Hs
		987641 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		K1H2_HUMAN (9-472): 2.19e-69: 230: 24.30
+	Hs
		300561 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		KRT36_HUMAN (27-431): 5.17e-68: 227: 26.23
+	Mm
		431366 SRC_MOUSE (161-215): 3.32e-10: 60.8: 31.58		K2C5_MOUSE (1-434): 1.45e-74: 248: 49.16
+	Hs
		473454 HCK_HUMAN (92-215): 4.76e-11: 63.5: 18.90		KRT35_HUMAN (9-479): 4.26e-70: 232: 24.58
+	Hs
		300546 HCK_HUMAN (92-215): 4.76e-11: 63.5: 18.90		KRT36_HUMAN (27-431): 5.17e-68: 227: 26.23