HitPredict

Interactor 1: P53 (P04637)
Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
Gene: TP53

Interactor 2: HSP74 (P34932)
Heat shock 70 kDa protein 4 (HSP70RY) (Heat shock 70-related protein APG-2) (Heat shock protein family H member 2)
Gene: HSPA4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	0.60	0.752

Property	Details
Experiments	25144556, 23109422, 30911017, 15004035, 32097779, 32807901, 18223694, 35140242, 20847049, 17184779, 21268072
Identification Methods	affinity chromatography technology, biochemical, x-ray crystallography
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005739 - mitochondrion GO:0005829 - cytosol
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 393 Hs			1 840
+	Hs
		320791 P53_HUMAN (1-393): 0: 619: 100.00		HS74L_HUMAN (1-840): 0: 959: 63.21
+	Hs
		387212 P53_HUMAN (1-393): 0: 619: 100.00		HS105_HUMAN (1-840): 0: 938: 62.95
+	Rn
		291978 P53_RAT (1-393): 0: 572: 77.02		HSP74_RAT (1-840): 0: 979: 95.83
+	Hs
		175831 P73_HUMAN (13-362): 2.35e-166: 481: 39.74		HSP74_HUMAN (1-840): 0: 993: 100.00
+	Hs
		714407 P63_HUMAN (28-363): 2.35e-145: 429: 42.11		HSP74_HUMAN (1-840): 0: 993: 100.00
+	Hs
		385979 P53_HUMAN (1-393): 0: 619: 100.00		HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92
+	Hs
		386199 P53_HUMAN (1-393): 0: 619: 100.00		HS71L_HUMAN (564-691): 7.22e-19: 93.5: 22.48
+	Hs
		386050 P53_HUMAN (1-393): 0: 619: 100.00		HSP76_HUMAN (587-690): 1.94e-16: 85.8: 22.86
+	Mm
		356821 P53_MOUSE (1-393): 0: 589: 77.35		HS71L_MOUSE (486-692): 1.89e-19: 95.5: 17.21
+	Mm
		356822 P53_MOUSE (1-393): 0: 589: 77.35		HS71B_MOUSE (571-686): 9.97e-18: 89.7: 23.08
+	Hs
		1093060 Q1MSW8_HUMAN (1-331): 0: 517: 99.70		Q53FC7_HUMAN (587-690): 3.01e-16: 85.1: 22.86